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325  structures 696  species 28  interactions 88541  sequences 6259  architectures

Clan: EGF (CL0001)

Summary

EGF superfamily Add an annotation

Members of this clan all belong to the EGF superfamily. This particular superfamily is characterised as having least 6 cysteines residues. These cysteine form disulphide bonds, in the order 1-3, 2-4, 5-6, which are essential for the stability of the EGF fold. These disulphide bonds are stacked in a ladder-like arrangement. The Laminin EGF family is distinguished by having an an additional disulphide bond. The function of the domains within this family remains unclear, but they are though to largely perform a structural role. More often than not, there domains are arranged a tandem repeats in extracellular proteins.

This clan contains 13 families and the total number of domains in the clan is 88541. The clan was built by RD Finn and A Bateman.

Literature references

  1. Appella E, Weber IT, Blasi F; , FEBS Lett 1988;231:1-4.: Structure and function of epidermal growth factor-like regions in proteins. PUBMED:3282918 EPMC:3282918
  2. Hohenester E, Engel J; , Matrix Biol 2002;21:115-128.: Domain structure and organisation in extracellular matrix proteins. PUBMED:11852228 EPMC:11852228

Members

This clan contains the following 13 member families:

cEGF DSL EGF EGF_2 EGF_3 EGF_alliinase EGF_CA EGF_MSP1_1 FOLN FXa_inhibition hEGF Laminin_EGF Tme5_EGF_like

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
EGF (PF00008) 24995 (28.2%) View
EGF_CA (PF07645) 24503 (27.7%) View
Laminin_EGF (PF00053) 16492 (18.6%) View
hEGF (PF12661) 6130 (6.9%) View
FXa_inhibition (PF14670) 5651 (6.4%) View
EGF_3 (PF12947) 4024 (4.5%) View
cEGF (PF12662) 2407 (2.7%) View
EGF_2 (PF07974) 1990 (2.2%) View
EGF_MSP1_1 (PF12946) 1331 (1.5%) View
DSL (PF01414) 522 (0.6%) View
FOLN (PF09289) 363 (0.4%) View
EGF_alliinase (PF04863) 87 (0.1%) View
Tme5_EGF_like (PF09064) 46 (0.1%) View
Total: 13 Total: 88541 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 28 interactions for this clan. More...

Interacting families
A B
FOLN Kazal_1
PRKCSH
EGF EGF
Ldl_recept_a
Lectin_C
Trypsin
CUB
Gla
Recep_L_domain
TSP_3
An_peroxidase
TSP_C
EGF_CA
EGF_2 Integrin_beta
FG-GAP
Integrin_B_tail
EGF_2
Integrin_alpha2
EGF_alliinase EGF_alliinase
Alliinase_C
EGF_CA EGF
Ldl_recept_b
CUB
TB
TSP_3
EGF_CA
Laminin_EGF Laminin_EGF
Ldl_recept_b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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