Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
742  structures 9904  species 4  interactions 23976  sequences 154  architectures

Clan: Histone (CL0012)

Summary

Histone superfamily Add an annotation

Members of this clan all possess a histone fold. Generally proteins in this clan are DNA binding.

This clan contains 11 families and the total number of domains in the clan is 23976. The clan was built by A Bateman.

Members

This clan contains the following 11 member families:

Bromo_TP CBFD_NFYB_HMF CENP-S CENP-T CENP-W Histone TAF TAFII28 TFIID-18kDa TFIID-31kDa TFIID_20kDa

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Histone (PF00125) 18172 (75.8%) View
CBFD_NFYB_HMF (PF00808) 2710 (11.3%) View
Bromo_TP (PF07524) 679 (2.8%) View
TFIID-18kDa (PF02269) 572 (2.4%) View
TAF (PF02969) 386 (1.6%) View
TFIID-31kDa (PF02291) 368 (1.5%) View
TFIID_20kDa (PF03847) 348 (1.5%) View
TAFII28 (PF04719) 332 (1.4%) View
CENP-S (PF15630) 231 (1.0%) View
CENP-T (PF15511) 140 (0.6%) View
CENP-W (PF15510) 38 (0.2%) View
Total: 11 Total: 23976 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls

Hide

This tree shows the occurrence of the domains in this clan across different species. More...

Loading...

Interactions

There are 4 interactions for this clan. More...

Interacting families
A B
Histone Histone
ASF1_hist_chap
CBFD_NFYB_HMF TBP
CBFD_NFYB_HMF

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...