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334  structures 7216  species 17  interactions 67224  sequences 418  architectures

Clan: Glutaminase_I (CL0014)

Summary

Class-I Glutamine amidotransferase superfamily Add an annotation

Most members of this clan are glutaminase enzymes. This superfamily is shown to be related in [1]. The clan also contains the DJ-1/PfpI family that includes the peptidase PfpI that has a catalytic Cys-His-Glu triad that differs from the class I GAT Cys-His-Glu triad.

This clan contains 13 families and the total number of domains in the clan is 67224. The clan was built by A Bateman.

Literature references

  1. Galperin MY, Grishin NV; , Proteins 2000;41:238-247.: The synthetase domains of cobalamin biosynthesis amidotransferases cobB and cobQ belong to a new family of ATP-dependent amidoligases, related to dethiobiotin synthetase. PUBMED:10966576 EPMC:10966576

Members

This clan contains the following 13 member families:

BPL_N DJ-1_PfpI DUF1355 DUF4066 GATase GATase_3 GATase_5 Glyco_hydro_42M HTS Peptidase_C26 Peptidase_S51 SNO ThuA

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GATase (PF00117) 29637 (44.1%) View
DJ-1_PfpI (PF01965) 9251 (13.8%) View
DUF4066 (PF13278) 5657 (8.4%) View
GATase_3 (PF07685) 5307 (7.9%) View
GATase_5 (PF13507) 4672 (6.9%) View
Peptidase_C26 (PF07722) 3232 (4.8%) View
HTS (PF04204) 2128 (3.2%) View
Peptidase_S51 (PF03575) 2034 (3.0%) View
SNO (PF01174) 1876 (2.8%) View
ThuA (PF06283) 1197 (1.8%) View
Glyco_hydro_42M (PF08532) 1054 (1.6%) View
DUF1355 (PF07090) 830 (1.2%) View
BPL_N (PF09825) 349 (0.5%) View
Total: 13 Total: 67224 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 17 interactions for this clan. More...

Interacting families
A B
Peptidase_C26 Peptidase_C26
SNO SNO
DJ-1_PfpI Catalase
DJ-1_PfpI
HTS HTS
GATase GATase
Chorismate_bind
GMP_synt_C
His_biosynth
CPSase_sm_chain
CPSase_L_D2
CPSase_L_D3
Anth_synt_I_N
CTP_synth_N
Glyco_hydro_42M Glyco_hydro_42
Glyco_hydro_42C
DUF1355 DUF1355

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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