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5523  structures 50680  species 208  interactions 1511292  sequences 12211  architectures

Clan: P-loop_NTPase (CL0023)

Summary

P-loop containing nucleoside triphosphate hydrolase superfamily Add an annotation

AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].

This clan contains 198 families and the total number of domains in the clan is 1511292. The clan was built by DJ Studholme.

Literature references

  1. Confalonieri F, Duguet M; , Bioessays 1995;17:639-650.: A 200-amino acid ATPase module in search of a basic function. PUBMED:7646486 EPMC:7646486
  2. Neuwald AF, Aravind L, Spouge JL, Koonin EV; , Genome Res 1999;9:27-43.: AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. PUBMED:9927482 EPMC:9927482
  3. Leipe DD, Wolf YI, Koonin EV, Aravind L;, J Mol Biol. 2002;317:41-72.: Classification and evolution of P-loop GTPases and related ATPases. PUBMED:11916378 EPMC:11916378
  4. Leipe DD, Koonin EV, Aravind L;, J Mol Biol. 2004;343:1-28.: STAND, a class of P-loop NTPases including animal and plant regulators of programmed cell death: multiple, complex domain architectures, unusual phyletic patterns, and evolution by horizontal gene transfer. PUBMED:15381417 EPMC:15381417
  5. Leipe DD, Koonin EV, Aravind L;, J Mol Biol. 2003;333:781-815.: Evolution and classification of P-loop kinases and related proteins. PUBMED:14568537 EPMC:14568537

Members

This clan contains the following 198 member families:

6PF2K AAA AAA-ATPase_like AAA_10 AAA_11 AAA_12 AAA_13 AAA_14 AAA_15 AAA_16 AAA_17 AAA_18 AAA_19 AAA_2 AAA_21 AAA_22 AAA_23 AAA_24 AAA_25 AAA_26 AAA_27 AAA_28 AAA_29 AAA_3 AAA_30 AAA_31 AAA_32 AAA_33 AAA_34 AAA_35 AAA_4 AAA_5 AAA_6 AAA_7 AAA_8 AAA_9 AAA_PrkA ABC_ATPase ABC_tran ABC_tran_2 Adeno_IVa2 Adenylsucc_synt ADK AFG1_ATPase AIG1 APS_kinase Arch_ATPase Arf ArgK ArsA_ATPase ATP-synt_ab ATP_bind_1 ATP_bind_2 Bac_DnaA CbiA CMS1 CoaE CobA_CobO_BtuR CobU cobW CPT CTP_synth_N Cytidylate_kin Cytidylate_kin2 DAP3 DEAD DEAD_2 DLIC DNA_pack_C DNA_pack_N DNA_pol3_delta DNA_pol3_delta2 DnaB_C dNK DUF1253 DUF1611 DUF2075 DUF2478 DUF258 DUF2791 DUF2813 DUF3584 DUF463 DUF815 DUF853 DUF87 DUF927 Dynamin_N Exonuc_V_gamma FeoB_N Fer4_NifH Flavi_DEAD FTHFS FtsK_SpoIIIE G-alpha Gal-3-0_sulfotr GBP GTP_EFTU GTP_EFTU_D2 GTP_EFTU_D4 Gtr1_RagA Guanylate_kin GvpD HDA2-3 Helicase_C Helicase_C_2 Helicase_C_4 Helicase_RecD Herpes_Helicase Herpes_ori_bp Herpes_TK IIGP IPPT IPT IstB_IS21 KaiC KAP_NTPase Kinesin Kinesin-relat_1 Kinesin-related KTI12 LpxK MCM MEDS Mg_chelatase Mg_chelatase_2 MipZ Miro MMR_HSR1 MobB MukB MutS_V Myosin_head NACHT NB-ARC NOG1 NTPase_1 ParA Parvo_NS1 PAXNEB PduV-EutP PhoH PIF1 Podovirus_Gp16 Polyoma_lg_T_C Pox_A32 PPK2 PPV_E1_C PRK Rad17 Rad51 Ras RecA ResIII RHD3 RHSP RNA12 RNA_helicase RuvB_N SbcCD_C SecA_DEAD Septin Sigma54_activ_2 Sigma54_activat SKI SMC_N SNF2_N Spore_IV_A SRP54 SRPRB Sulfotransfer_1 Sulfotransfer_2 Sulfotransfer_3 Sulphotransf T2SE T4SS-DNA_transf Terminase_1 Terminase_3 Terminase_6 Terminase_GpA Thymidylate_kin TIP49 TK TniB Torsin TraG-D_C tRNA_lig_kinase TrwB_AAD_bind UPF0079 UvrD-helicase UvrD_C UvrD_C_2 Viral_helicase1 VirC1 VirE YhjQ Zeta_toxin Zot

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
ABC_tran (PF00005) 363409 (24.0%) View
Helicase_C (PF00271) 89228 (5.9%) View
GTP_EFTU (PF00009) 69868 (4.6%) View
DEAD (PF00270) 63415 (4.2%) View
GTP_EFTU_D2 (PF03144) 58968 (3.9%) View
AAA (PF00004) 52090 (3.4%) View
MMR_HSR1 (PF01926) 46032 (3.0%) View
ATP-synt_ab (PF00006) 33595 (2.2%) View
Sigma54_activat (PF00158) 23376 (1.5%) View
Ras (PF00071) 21243 (1.4%) View
AAA_2 (PF07724) 20963 (1.4%) View
CbiA (PF01656) 20629 (1.4%) View
Fer4_NifH (PF00142) 20327 (1.3%) View
ResIII (PF04851) 18536 (1.2%) View
UvrD-helicase (PF00580) 18162 (1.2%) View
UvrD_C (PF13361) 17009 (1.1%) View
NB-ARC (PF00931) 16257 (1.1%) View
ABC_tran_2 (PF12848) 15857 (1.0%) View
SNF2_N (PF00176) 15349 (1.0%) View
T2SE (PF00437) 13216 (0.9%) View
SMC_N (PF02463) 12849 (0.9%) View
RecA (PF00154) 12149 (0.8%) View
SRP54 (PF00448) 11362 (0.8%) View
AAA_5 (PF07728) 10563 (0.7%) View
cobW (PF02492) 9942 (0.7%) View
FtsK_SpoIIIE (PF01580) 9858 (0.7%) View
Kinesin (PF00225) 9740 (0.6%) View
ADK (PF00406) 9734 (0.6%) View
MutS_V (PF00488) 9697 (0.6%) View
DNA_pol3_delta2 (PF13177) 9575 (0.6%) View
PRK (PF00485) 8151 (0.5%) View
Guanylate_kin (PF00625) 8050 (0.5%) View
Myosin_head (PF00063) 7667 (0.5%) View
AAA_31 (PF13614) 7392 (0.5%) View
IstB_IS21 (PF01695) 7213 (0.5%) View
SKI (PF01202) 7157 (0.5%) View
AAA_25 (PF13481) 6612 (0.4%) View
AAA_10 (PF12846) 6551 (0.4%) View
Dynamin_N (PF00350) 6429 (0.4%) View
Flavi_DEAD (PF07652) 6300 (0.4%) View
Bac_DnaA (PF00308) 6279 (0.4%) View
DnaB_C (PF03796) 6233 (0.4%) View
UvrD_C_2 (PF13538) 6202 (0.4%) View
PhoH (PF02562) 6190 (0.4%) View
AAA_21 (PF13304) 6048 (0.4%) View
AAA_23 (PF13476) 5945 (0.4%) View
SecA_DEAD (PF07517) 5907 (0.4%) View
Helicase_C_2 (PF13307) 5901 (0.4%) View
NACHT (PF05729) 5874 (0.4%) View
RuvB_N (PF05496) 5721 (0.4%) View
AAA_12 (PF13087) 5685 (0.4%) View
AAA_11 (PF13086) 5668 (0.4%) View
Arf (PF00025) 5460 (0.4%) View
Adenylsucc_synt (PF00709) 5395 (0.4%) View
IPPT (PF01715) 5290 (0.4%) View
CTP_synth_N (PF06418) 5282 (0.3%) View
AAA_26 (PF13500) 5230 (0.3%) View
AAA_30 (PF13604) 5200 (0.3%) View
Thymidylate_kin (PF02223) 5133 (0.3%) View
ParA (PF10609) 4990 (0.3%) View
CoaE (PF01121) 4826 (0.3%) View
FTHFS (PF01268) 4825 (0.3%) View
AAA_16 (PF13191) 4712 (0.3%) View
Sulfotransfer_1 (PF00685) 4587 (0.3%) View
UPF0079 (PF02367) 4392 (0.3%) View
AAA_22 (PF13401) 4268 (0.3%) View
DUF258 (PF03193) 4240 (0.3%) View
Mg_chelatase (PF01078) 4229 (0.3%) View
DNA_pol3_delta (PF06144) 4182 (0.3%) View
Cytidylate_kin (PF02224) 4159 (0.3%) View
AAA_3 (PF07726) 4128 (0.3%) View
AAA_33 (PF13671) 4032 (0.3%) View
RNA_helicase (PF00910) 3937 (0.3%) View
SbcCD_C (PF13558) 3904 (0.3%) View
MCM (PF00493) 3858 (0.3%) View
FeoB_N (PF02421) 3662 (0.2%) View
ATP_bind_2 (PF03668) 3506 (0.2%) View
DEAD_2 (PF06733) 3488 (0.2%) View
AAA_14 (PF13173) 3483 (0.2%) View
TK (PF00265) 3293 (0.2%) View
AAA_17 (PF13207) 3187 (0.2%) View
Mg_chelatase_2 (PF13335) 3113 (0.2%) View
APS_kinase (PF01583) 3100 (0.2%) View
Terminase_6 (PF03237) 3063 (0.2%) View
PPK2 (PF03976) 2990 (0.2%) View
G-alpha (PF00503) 2902 (0.2%) View
AAA_19 (PF13245) 2781 (0.2%) View
Viral_helicase1 (PF01443) 2712 (0.2%) View
AFG1_ATPase (PF03969) 2702 (0.2%) View
ArsA_ATPase (PF02374) 2686 (0.2%) View
MobB (PF03205) 2671 (0.2%) View
AAA_4 (PF04326) 2671 (0.2%) View
Septin (PF00735) 2609 (0.2%) View
PIF1 (PF05970) 2557 (0.2%) View
CobA_CobO_BtuR (PF02572) 2528 (0.2%) View
T4SS-DNA_transf (PF02534) 2504 (0.2%) View
dNK (PF01712) 2493 (0.2%) View
AAA_18 (PF13238) 2477 (0.2%) View
Rad51 (PF08423) 2467 (0.2%) View
LpxK (PF02606) 2466 (0.2%) View
continued
Pfam family Num. domains Alignment
AAA_6 (PF12774) 2434 (0.2%) View
Terminase_1 (PF03354) 2382 (0.2%) View
CobU (PF02283) 2330 (0.2%) View
AAA_9 (PF12781) 2170 (0.1%) View
AAA_8 (PF12780) 2160 (0.1%) View
Sulfotransfer_2 (PF03567) 2144 (0.1%) View
Exonuc_V_gamma (PF04257) 2140 (0.1%) View
AAA_7 (PF12775) 2098 (0.1%) View
ATP_bind_1 (PF03029) 1967 (0.1%) View
KaiC (PF06745) 1953 (0.1%) View
AAA_27 (PF13514) 1921 (0.1%) View
AAA_28 (PF13521) 1816 (0.1%) View
Sulfotransfer_3 (PF13469) 1788 (0.1%) View
AIG1 (PF04548) 1778 (0.1%) View
Polyoma_lg_T_C (PF06431) 1776 (0.1%) View
Arch_ATPase (PF01637) 1765 (0.1%) View
ArgK (PF03308) 1738 (0.1%) View
Terminase_GpA (PF05876) 1654 (0.1%) View
AAA-ATPase_like (PF09820) 1607 (0.1%) View
Miro (PF08477) 1563 (0.1%) View
AAA_32 (PF13654) 1541 (0.1%) View
TraG-D_C (PF12696) 1419 (0.1%) View
AAA_PrkA (PF08298) 1391 (0.1%) View
Helicase_RecD (PF05127) 1317 (0.1%) View
DUF853 (PF05872) 1311 (0.1%) View
Zeta_toxin (PF06414) 1247 (0.1%) View
Parvo_NS1 (PF01057) 1228 (0.1%) View
KAP_NTPase (PF07693) 1164 (0.1%) View
VirE (PF05272) 1163 (0.1%) View
6PF2K (PF01591) 1160 (0.1%) View
DUF815 (PF05673) 1159 (0.1%) View
DUF87 (PF01935) 1158 (0.1%) View
PduV-EutP (PF10662) 1157 (0.1%) View
GBP (PF02263) 1135 (0.1%) View
PPV_E1_C (PF00519) 1112 (0.1%) View
Cytidylate_kin2 (PF13189) 1110 (0.1%) View
DUF463 (PF04317) 1031 (0.1%) View
Terminase_3 (PF04466) 1027 (0.1%) View
AAA_15 (PF13175) 1024 (0.1%) View
Pox_A32 (PF04665) 981 (0.1%) View
Herpes_Helicase (PF02689) 968 (0.1%) View
TIP49 (PF06068) 859 (0.1%) View
RHSP (PF07999) 829 (0.1%) View
DUF2813 (PF11398) 824 (0.1%) View
AAA_29 (PF13555) 804 (0.1%) View
DUF927 (PF06048) 800 (0.1%) View
DUF2075 (PF09848) 776 (0.1%) View
MukB (PF04310) 745 (0.0%) View
Gtr1_RagA (PF04670) 723 (0.0%) View
Sigma54_activ_2 (PF14532) 695 (0.0%) View
TrwB_AAD_bind (PF10412) 675 (0.0%) View
YhjQ (PF06564) 638 (0.0%) View
AAA_13 (PF13166) 601 (0.0%) View
Gal-3-0_sulfotr (PF06990) 598 (0.0%) View
Zot (PF05707) 575 (0.0%) View
AAA_24 (PF13479) 566 (0.0%) View
Herpes_TK (PF00693) 508 (0.0%) View
NOG1 (PF06858) 503 (0.0%) View
DLIC (PF05783) 500 (0.0%) View
AAA_34 (PF13872) 492 (0.0%) View
Helicase_C_4 (PF13871) 482 (0.0%) View
AAA_35 (PF14516) 465 (0.0%) View
ABC_ATPase (PF09818) 462 (0.0%) View
RHD3 (PF05879) 439 (0.0%) View
MipZ (PF09140) 431 (0.0%) View
Spore_IV_A (PF09547) 421 (0.0%) View
KTI12 (PF08433) 408 (0.0%) View
Rad17 (PF03215) 406 (0.0%) View
Torsin (PF06309) 383 (0.0%) View
DUF1253 (PF06862) 368 (0.0%) View
DAP3 (PF10236) 361 (0.0%) View
SRPRB (PF09439) 357 (0.0%) View
IIGP (PF05049) 355 (0.0%) View
GTP_EFTU_D4 (PF14578) 354 (0.0%) View
NTPase_1 (PF03266) 349 (0.0%) View
DUF1611 (PF07755) 333 (0.0%) View
PAXNEB (PF05625) 316 (0.0%) View
DUF2791 (PF10923) 286 (0.0%) View
TniB (PF05621) 273 (0.0%) View
MEDS (PF14417) 260 (0.0%) View
DNA_pack_C (PF02499) 252 (0.0%) View
CMS1 (PF14617) 248 (0.0%) View
Herpes_ori_bp (PF02399) 207 (0.0%) View
DUF2478 (PF10649) 205 (0.0%) View
CPT (PF07931) 191 (0.0%) View
Sulphotransf (PF09037) 172 (0.0%) View
RNA12 (PF10443) 149 (0.0%) View
DNA_pack_N (PF02500) 149 (0.0%) View
HDA2-3 (PF11496) 146 (0.0%) View
DUF3584 (PF12128) 142 (0.0%) View
tRNA_lig_kinase (PF08303) 141 (0.0%) View
Adeno_IVa2 (PF02456) 128 (0.0%) View
Kinesin-relat_1 (PF12711) 117 (0.0%) View
Kinesin-related (PF06548) 95 (0.0%) View
IPT (PF01745) 88 (0.0%) View
VirC1 (PF07015) 74 (0.0%) View
GvpD (PF07088) 21 (0.0%) View
Podovirus_Gp16 (PF05894) 17 (0.0%) View
Total: 198 Total: 1511292 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

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Species distribution

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Interactions

There are 208 interactions for this clan. More...

Interacting families
A B
Sigma54_activat Response_reg
Sigma54_activat
Zeta_toxin Epsilon_antitox
ArgK ArgK
G-alpha Guanylate_cyc
WD40
G-alpha
Thymidylate_kin Thymidylate_kin
SNF2_N SNF2_N
Helicase_C
Bac_DnaA Bac_DnaA
Bac_DnaA_C
Sulphotransf Sulphotransf
CbiA CbiA
SecA_DEAD Helicase_C
SecA_PP_bind
SecA_SW
TrwB_AAD_bind TrwB_AAD_bind
Cytidylate_kin Cytidylate_kin
KaiC KaiC
TIP49 AAA
TIP49
PRK PRK
CoaE CoaE
Fer4_NifH Fer4_NifH
Oxidored_nitro
Rad51 HHH
Rad51
Herpes_TK Herpes_TK
TK TK
IIGP IIGP
RecA RecA
T2SE T2SE
GTP_EFTU GTP_EFTU
UBA
EFG_C
EF1_GNE
EF_TS
PAPS_reduct
eIF-5_eIF-2B
GTP_EFTU_D3
GTP_EFTU_D2
EFG_IV
eIF2_C
MMR_HSR1 GTP1_OBG
MMR_HSR1
YchF-GTPase_C
KH_2
TrmE_N
CobA_CobO_BtuR CobA_CobO_BtuR
DnaB_C DnaB
DnaB_C
GTP_EFTU_D2 GTP_EFTU
EF1_GNE
PAPS_reduct
GTP_EFTU_D3
GTP_EFTU_D2
EFG_IV
EIF_2_alpha
eIF2_C
ResIII Helicase_C
UVR
ResIII
SKI SKI
MutS_V MutS_V
MutS_II
MutS_III
GBP GBP
GBP_C
dNK dNK
ATP-synt_ab ATP-synt_ab
ATP-synt
ATP-synt_ab_C
ATP-synt_ab_N
CobU CobU
AAA AAA
Peptidase_M41
CDC48_N
Clp_N
CDC48_2
RuvB_C
RuvB_N
TIP49
DNA_pol3_delta
RuvA_C
AAA_2
Rep_fac_C
Vps4_C
AAA_2 AAA
Proteasome
AAA_2
ClpB_D2-small
Adenylsucc_synt Adenylsucc_synt
Flavi_DEAD Helicase_C
Peptidase_S7
Peptidase_S29
Flavi_DEAD
ArsA_ATPase ArsA_ATPase
Arf Arf
Gelsolin
Sec7
Sec23_trunk
Sec23_helical
GMP_PDE_delta
Dynamin_N Myosin_head
Dynamin_N
Parvo_NS1 Parvo_NS1
DEAD DEAD
Helicase_C
Toprim
Mago_nashi
RQC
Btz
Arch_ATPase Arch_ATPase
ParA ParA
MobB MobB
DUF1611 DUF1611
Kinesin Tubulin
Kinesin
Tubulin_C
SRP54 SRP54
SRP54_N
SRP_SPB
CPT CPT
6PF2K His_Phos_1
6PF2K
PhoH PhoH
Septin Septin
Guanylate_kin Guanylate_kin
SH3_2
Ras Ras
PH
RCC1
PI3_PI4_kinase
TPR_1
RabGAP-TBC
PDZ
RasGAP
RasGEF
RasGEF_N
RhoGAP
RhoGEF
Ran_BP1
PI3K_rbd
GDI
TIG
Rho_GDI
NTF2
HR1
RBD
VPS9
HEAT
ADPrib_exo_Tox
YopE
IBN_N
Mss4
Drf_GBD
Rho_Binding
RBD-FIP
Rbsn
cobW cobW
CobW_C
Myosin_head Actin
EF-hand_1
Myosin_head
Dynamin_N
IQ
Myosin_N
EFhand_Ca_insen
RuvB_N AAA
DUF258 DUF258
Helicase_C SNF2_N
DEAD
Helicase_C
UVR
Mago_nashi
ResIII
SecA_SW
SecA_DEAD
Flavi_DEAD
UPF0079 UPF0079
ATP_bind_1 ATP_bind_1
APS_kinase APS_kinase
ATP-sulfurylase
FtsK_SpoIIIE FtsK_SpoIIIE
ABC_tran ABC_tran
BPD_transp_1
ABC_membrane
FecCD
TOBE_2
CTP_synth_N GATase
CTP_synth_N
AIG1 AIG1
DNA_pol3_delta AAA
DNA_pol3_beta_2
DNA_pol3_beta_3
DNA_pol3_delta
DNApol3-delta_C
ADK ADK
ADK_lid
FTHFS FTHFS
Sulfotransfer_1 Sulfotransfer_1
NB-ARC Bcl-2
CARD
NB-ARC
BH4
UvrD-helicase UvrD-helicase
SRPRB SRX

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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