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1015  structures 19953  species 28  interactions 63536  sequences 245  architectures

Clan: CU_oxidase (CL0026)

Summary

Multicopper oxidase-like domain Add an annotation

Many of the proteins in this family contain multiple similar copies of this plastocyanin-like domain.

This clan contains 9 families and the total number of domains in the clan is 63536. The clan was built by DJ Studholme and RD Finn.

Literature references

  1. Messerschmidt A, Huber R; , Eur J Biochem 1990;187:341-352.: The blue oxidases, ascorbate oxidase, laccase and ceruloplasmin. Modelling and structural relationships. PUBMED:2404764 EPMC:2404764
  2. Messerschmidt A, Ladenstein R, Huber R, Bolognesi M, Avigliano L, Petruzzelli R, Rossi A, Finazzi-Agro A; , J Mol Biol 1992;224:179-205.: Refined crystal structure of ascorbate oxidase at 1.9 A resolution. PUBMED:1548698 EPMC:1548698
  3. Page CC, Moser CC, Chen X, Dutton PL; , Nature 1999;402:47-52.: Natural engineering principles of electron tunnelling in biological oxidation-reduction. PUBMED:10573417 EPMC:10573417
  4. Grossmann JG, Ingledew WJ, Harvey I, Strange RW, Hasnain SS; , Biochemistry 1995;34:8406-8414.: X-ray absorption studies and homology modeling define the structural features that specify the nature of the copper site in rusticyanin. PUBMED:7599131 EPMC:7599131

Members

This clan contains the following 9 member families:

Copper-bind COX2 Cu-oxidase Cu-oxidase_2 Cu-oxidase_3 Cu_bind_like Cupredoxin_1 Ephrin SoxE

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
COX2 (PF00116) 31269 (49.2%) View
Cu-oxidase_3 (PF07732) 9918 (15.6%) View
Cu-oxidase (PF00394) 9871 (15.5%) View
Cu-oxidase_2 (PF07731) 6906 (10.9%) View
Cupredoxin_1 (PF13473) 2319 (3.6%) View
Copper-bind (PF00127) 1467 (2.3%) View
Cu_bind_like (PF02298) 1166 (1.8%) View
Ephrin (PF00812) 554 (0.9%) View
SoxE (PF06525) 66 (0.1%) View
Total: 9 Total: 63536 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 28 interactions for this clan. More...

Interacting families
A B
Cu_bind_like Cu_bind_like
COX2 Cytochrom_C
COX1
COX2
COX3
COX6B
COX2_TM
COX4
COX6C
COX_ARM
COX4_pro_2
CoxIIa
Copper-bind Cytochrom_C
Copper-bind
Cu-oxidase
Me-amine-dh_L
Me-amine-dh_H
Cu-oxidase_3
Cu-oxidase Copper-bind
Cu-oxidase
Cu-oxidase_2
Cu-oxidase_3
Cu-oxidase_3 Copper-bind
Cu-oxidase
Cu-oxidase_2
Cu-oxidase_3
Cu-oxidase_2 Cu-oxidase
Cu-oxidase_3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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