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718  structures 5250  species 3  interactions 44250  sequences 809  architectures

Clan: Ion_channel (CL0030)

Summary

Ion channel (VIC) superfamily Add an annotation

This superfamily contains a diverse range of ion channels that share a pair of transmembrane helices in common. This clan is classified as the VIC (Voltage-gated Ion Channel) superfamily in TCDB.

This clan contains 8 families and the total number of domains in the clan is 44250. The clan was built by A Bateman.

Members

This clan contains the following 8 member families:

GLTSCR1 Ion_trans Ion_trans_2 IRK KdpA Lig_chan PKD_channel TrkH

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Ion_trans (PF00520) 20399 (46.1%) View
Ion_trans_2 (PF07885) 9163 (20.7%) View
TrkH (PF02386) 6295 (14.2%) View
Lig_chan (PF00060) 3260 (7.4%) View
KdpA (PF03814) 2239 (5.1%) View
IRK (PF01007) 1452 (3.3%) View
PKD_channel (PF08016) 1249 (2.8%) View
GLTSCR1 (PF15249) 193 (0.4%) View
Total: 8 Total: 44250 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 3 interactions for this clan. More...

Interacting families
A B
IRK IRK
Ion_trans_2 V-set
Ion_trans_2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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