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480  structures 2966  species 7  interactions 20482  sequences 558  architectures

Clan: Phosphatase (CL0031)

Summary

Phosphatase superfamily Add an annotation

This family includes tyrosine and dual specificity phosphatase enzymes.

This clan contains 9 families and the total number of domains in the clan is 20482. The clan was built by A Bateman.

Literature references

  1. Barford D, Das AK, Egloff MP; , Annu Rev Biophys Biomol Struct 1998;27:133-164.: The structure and mechanism of protein phosphatases: insights into catalysis and regulation. PUBMED:9646865 EPMC:9646865

Members

This clan contains the following 9 member families:

CDKN3 DSPc DUF442 Init_tRNA_PT Myotub-related PTPlike_phytase Y_phosphatase Y_phosphatase2 Y_phosphatase3

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Y_phosphatase (PF00102) 7626 (37.2%) View
DSPc (PF00782) 6758 (33.0%) View
Myotub-related (PF06602) 1877 (9.2%) View
Y_phosphatase3 (PF13350) 1860 (9.1%) View
DUF442 (PF04273) 718 (3.5%) View
Y_phosphatase2 (PF03162) 714 (3.5%) View
PTPlike_phytase (PF14566) 540 (2.6%) View
Init_tRNA_PT (PF04179) 202 (1.0%) View
CDKN3 (PF05706) 187 (0.9%) View
Total: 9 Total: 20482 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 7 interactions for this clan. More...

Interacting families
A B
CDKN3 Pkinase
CDKN3
DUF442 DUF442
DSPc DSPc
Y_phosphatase SH2
Y_phosphatase
Pkinase_Tyr

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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