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704  structures 5687  species 18  interactions 79783  sequences 479  architectures

Clan: Amidohydrolase (CL0034)

Summary

Amidohydrolase superfamily Add an annotation

This family includes a large family of metal dependent amidohydrolase enzymes [1].

This clan contains 16 families and the total number of domains in the clan is 79783. The clan was built by A Bateman.

Literature references

  1. Holm L, Sander C; , Proteins 1997;28:72-82.: An evolutionary treasure: unification of a broad set of amidohydrolases related to urease. PUBMED:9144792 EPMC:9144792

Members

This clan contains the following 16 member families:

A_deaminase Amidohydro_1 Amidohydro_2 Amidohydro_3 Amidohydro_4 Amidohydro_5 DHOase DUF3604 Peptidase_M19 PHP PHP_C PTE RNase_P_p30 TatD_DNase Urease_alpha UxaC

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Amidohydro_1 (PF01979) 18418 (23.1%) View
PHP (PF02811) 14520 (18.2%) View
Amidohydro_4 (PF13147) 10639 (13.3%) View
TatD_DNase (PF01026) 8430 (10.6%) View
Amidohydro_2 (PF04909) 6287 (7.9%) View
Amidohydro_3 (PF07969) 5270 (6.6%) View
A_deaminase (PF00962) 4245 (5.3%) View
Amidohydro_5 (PF13594) 3712 (4.7%) View
Peptidase_M19 (PF01244) 2249 (2.8%) View
Urease_alpha (PF00449) 1905 (2.4%) View
UxaC (PF02614) 1495 (1.9%) View
PTE (PF02126) 1183 (1.5%) View
PHP_C (PF13263) 736 (0.9%) View
RNase_P_p30 (PF01876) 477 (0.6%) View
DUF3604 (PF12228) 171 (0.2%) View
DHOase (PF12890) 46 (0.1%) View
Total: 16 Total: 79783 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 18 interactions for this clan. More...

Interacting families
A B
Urease_alpha Urease_beta
Amidohydro_1
PTE PTE
UxaC UxaC
Amidohydro_3 D-aminoacyl_C
Amidohydro_3
Amidohydro_1 Urease_alpha
Urease_gamma
Urease_beta
Amidohydro_1
PHP PHP
DNA_pol3_alpha
Peptidase_M19 Peptidase_M19
TatD_DNase TatD_DNase
Amidohydro_2 Amidohydro_2
A_deaminase DPPIV_N
A_deaminase
RNase_P_p30 RNase_P_Rpp14

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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