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603  structures 4350  species 14  interactions 23892  sequences 332  architectures

Clan: NTF2 (CL0051)

Summary

NTF2-like superfamily Add an annotation

This superfamily contains a variety of enzymes such as Scytalone dehydratase, Delta-5-3-ketosteroid isomerase, Limonene-1,2-epoxide hydrolase among others. The family also includes presumed non-enzymatic homologues such as NTF2.

This clan contains 24 families and the total number of domains in the clan is 23892. The clan was built by A Bateman.

Literature references

  1. Nagata Y, Mori K, Takagi M, Murzin AG, Damborsky J; , Proteins 2001;45:471-477.: Identification of protein fold and catalytic residues of gamma-hexachlorocyclohexane dehydrochlorinase LinA. PUBMED:11746694 EPMC:11746694

Members

This clan contains the following 24 member families:

CaMKII_AD DUF1348 DUF2358 DUF3225 DUF3804 DUF4440 DUF4467 LEH Lumazine_bd Lumazine_bd_2 MBA1 MecA_N Mtr2 NTF2 PHZA_PHZB Ring_hydroxyl_B Scytalone_dh SnoaL SnoaL_2 SnoaL_3 SnoaL_4 Tim44 VirB8 WI12

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SnoaL_2 (PF12680) 6223 (26.0%) View
SnoaL_4 (PF13577) 2151 (9.0%) View
DUF4440 (PF14534) 1968 (8.2%) View
NTF2 (PF02136) 1695 (7.1%) View
Tim44 (PF04280) 1637 (6.9%) View
VirB8 (PF04335) 1418 (5.9%) View
Ring_hydroxyl_B (PF00866) 1346 (5.6%) View
SnoaL_3 (PF13474) 1249 (5.2%) View
SnoaL (PF07366) 1134 (4.7%) View
MecA_N (PF05223) 954 (4.0%) View
CaMKII_AD (PF08332) 782 (3.3%) View
Lumazine_bd (PF12870) 650 (2.7%) View
DUF1348 (PF07080) 617 (2.6%) View
continued
Pfam family Num. domains Alignment
DUF4467 (PF14729) 517 (2.2%) View
DUF2358 (PF10184) 393 (1.6%) View
Lumazine_bd_2 (PF12893) 306 (1.3%) View
DUF3225 (PF11533) 251 (1.1%) View
LEH (PF07858) 167 (0.7%) View
Scytalone_dh (PF02982) 125 (0.5%) View
PHZA_PHZB (PF03284) 88 (0.4%) View
WI12 (PF07107) 77 (0.3%) View
MBA1 (PF07961) 74 (0.3%) View
Mtr2 (PF10429) 52 (0.2%) View
DUF3804 (PF12707) 18 (0.1%) View
Total: 24 Total: 23892 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 14 interactions for this clan. More...

Interacting families
A B
DUF3225 DUF3225
CaMKII_AD CaMKII_AD
Tim44 Tim44
SnoaL SnoaL
MecA_N PBP_dimer
Scytalone_dh Scytalone_dh
NTF2 Ras
NTF2
Carot_N
Ring_hydroxyl_B Rieske
Ring_hydroxyl_A
Ring_hydroxyl_B
DUF1348 DUF1348
LEH LEH

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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