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185  structures 3932  species 9  interactions 18127  sequences 88  architectures

Clan: Met_repress (CL0057)

Summary

MetJ/Arc repressor superfamily Add an annotation

This superfamily contains the MetJ and Arc repressors that feature a ribbon-helix-helix DNA-binding motif with the beta-ribbon located in and recognising the major groove of operator DNA [1].

This clan contains 21 families and the total number of domains in the clan is 18127. The clan was built by A Bateman.

Literature references

  1. Murayama K, Orth P, de la Hoz AB, Alonso JC, Saenger W; , J Mol Biol 2001;314:789-796.: Crystal structure of omega transcriptional repressor encoded by Streptococcus pyogenes plasmid pSM19035 at 1.5 A resolution. PUBMED:11733997 EPMC:11733997

Members

This clan contains the following 21 member families:

Arc CcdA DUF1662 DUF1778 DUF2191 DUF2610 DUF3423 DUF3924 HicB MetJ Omega_Repress ParD ParG PSK_trans_fac RelB RepB-RCR_reg RHH_1 RHH_2 RHH_3 RHH_4 TraY

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
RHH_1 (PF01402) 5913 (32.6%) View
RelB (PF04221) 2614 (14.4%) View
DUF1778 (PF08681) 1442 (8.0%) View
HicB (PF05534) 1200 (6.6%) View
RHH_2 (PF03693) 1166 (6.4%) View
MetJ (PF01340) 798 (4.4%) View
Arc (PF03869) 753 (4.2%) View
DUF2191 (PF09957) 685 (3.8%) View
CcdA (PF07362) 640 (3.5%) View
RHH_4 (PF13467) 610 (3.4%) View
DUF3423 (PF11903) 485 (2.7%) View
continued
Pfam family Num. domains Alignment
RepB-RCR_reg (PF10723) 388 (2.1%) View
RHH_3 (PF12651) 354 (2.0%) View
PSK_trans_fac (PF07704) 347 (1.9%) View
TraY (PF05509) 257 (1.4%) View
Omega_Repress (PF07764) 125 (0.7%) View
ParG (PF09274) 92 (0.5%) View
DUF3924 (PF13062) 84 (0.5%) View
DUF1662 (PF07878) 70 (0.4%) View
DUF2610 (PF11020) 66 (0.4%) View
ParD (PF09386) 38 (0.2%) View
Total: 21 Total: 18127 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 9 interactions for this clan. More...

Interacting families
A B
ParD ParD
DUF1778 DUF1778
CcdA CcdA
MetJ MetJ
Omega_Repress Omega_Repress
RHH_1 RHH_1
NikR_C
Arc Arc
ParG ParG

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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