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36  structures 5587  species 0  interactions 126928  sequences 417  architectures

Clan: APC (CL0062)

Summary

APC superfamily Add an annotation

This large superfamily contains a variety of transporters including amino acid permeases that according to TCDB belong to the APC (Amino acid-Polyamine-organoCation) superfamily.

This clan contains 18 families and the total number of domains in the clan is 126928. The clan was built by A Bateman.

Members

This clan contains the following 18 member families:

AA_permease AA_permease_2 AA_permease_C Aa_trans BenE Branch_AA_trans CstA HCO3_cotransp K_trans Na_Ala_symp Nramp Spore_permease SSF Sulfate_tra_GLY Sulfate_transp Transp_cyt_pur Trp_Tyr_perm Xan_ur_permease

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
AA_permease_2 (PF13520) 23261 (18.3%) View
AA_permease (PF00324) 17705 (13.9%) View
Xan_ur_permease (PF00860) 15557 (12.3%) View
SSF (PF00474) 13052 (10.3%) View
Sulfate_transp (PF00916) 7799 (6.1%) View
Sulfate_tra_GLY (PF13792) 6864 (5.4%) View
Aa_trans (PF01490) 6390 (5.0%) View
Na_Ala_symp (PF01235) 5556 (4.4%) View
Nramp (PF01566) 5115 (4.0%) View
Trp_Tyr_perm (PF03222) 4713 (3.7%) View
Transp_cyt_pur (PF02133) 4605 (3.6%) View
Branch_AA_trans (PF05525) 3775 (3.0%) View
CstA (PF02554) 3680 (2.9%) View
K_trans (PF02705) 2676 (2.1%) View
HCO3_cotransp (PF00955) 2233 (1.8%) View
Spore_permease (PF03845) 1773 (1.4%) View
BenE (PF03594) 1251 (1.0%) View
AA_permease_C (PF13906) 923 (0.7%) View
Total: 18 Total: 126928 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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