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659  structures 1705  species 20  interactions 12929  sequences 720  architectures

Clan: Trefoil (CL0066)

Summary

Beta-trefoil superfamily Add an annotation

This family corresponds to a large set of related beta-trefoil proteins [1]. The beta-trefoil is formed by six two-stranded hairpins [2]. Three of these form a barrel structure and the other three are in a triangular array that caps the barrel. The arrangement of the secondary structures gives the molecules a pseudo 3-fold axis.

This clan contains 15 families and the total number of domains in the clan is 12929. The clan was built by A Bateman.

Literature references

  1. Ponting CP, Russell RB; , J Mol Biol 2000;302:1041-1047.: Identification of distant homologues of fibroblast growth factors suggests a common ancestor for all beta-trefoil proteins. PUBMED:11183773 EPMC:11183773
  2. Murzin AG, Lesk AM, Chothia C; , J Mol Biol 1992;223:531-543.: beta-Trefoil fold. Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors. PUBMED:1738162 EPMC:1738162

Members

This clan contains the following 15 member families:

AbfB Agglutinin Botulinum_HA-17 CDtoxinA DUF569 Fascin FGF FRG1 IL1 Ins145_P3_rec Kunitz_legume MIR Ricin_B_lectin RicinB_lectin_2 Toxin_R_bind_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Ricin_B_lectin (PF00652) 3906 (30.2%) View
FGF (PF00167) 1638 (12.7%) View
MIR (PF02815) 1582 (12.2%) View
RicinB_lectin_2 (PF14200) 1501 (11.6%) View
Fascin (PF06268) 817 (6.3%) View
Kunitz_legume (PF00197) 766 (5.9%) View
Ins145_P3_rec (PF08709) 714 (5.5%) View
IL1 (PF00340) 589 (4.6%) View
CDtoxinA (PF03498) 430 (3.3%) View
AbfB (PF05270) 334 (2.6%) View
FRG1 (PF06229) 253 (2.0%) View
DUF569 (PF04601) 184 (1.4%) View
Toxin_R_bind_C (PF07951) 143 (1.1%) View
Agglutinin (PF07468) 39 (0.3%) View
Botulinum_HA-17 (PF05588) 33 (0.3%) View
Total: 15 Total: 12929 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 20 interactions for this clan. More...

Interacting families
A B
Ricin_B_lectin RIP
Glyco_hydro_10
Glycos_transf_2
Ricin_B_lectin
Leukocidin
Toxin_R_bind_C Toxin_trans
Toxin_R_bind_N
Agglutinin Agglutinin
IL1 ig
IL1
CDtoxinA Exo_endo_phos
CDtoxinA
AbfB ArabFuran-catal
FGF ig
FGF
I-set
Fascin Fascin
Kunitz_legume Thioredoxin
Alpha-amylase
Kunitz_legume

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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