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614  structures 5455  species 2  interactions 48240  sequences 141  architectures

Clan: ALDH-like (CL0099)

Summary

ALDH-like superfamily Add an annotation

The aldehyde dehydrogenases (ALDHs) are a superfamily of multimeric enzymes which catalyse the oxidation of a broad range of aldehydes into their corresponding carboxylic acids with the reduction of their cofactor, NAD(P) into NAD(P)H. The way that the NAD is bound is distinct from other NAD(P)-dependent oxidoreductases. The domain represented by this clan consists of two similar subdomains.

This clan contains 4 families and the total number of domains in the clan is 48240. The clan was built by RD Finn.

Members

This clan contains the following 4 member families:

Aldedh DUF1487 Histidinol_dh LuxC

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Aldedh (PF00171) 43773 (90.7%) View
Histidinol_dh (PF00815) 3998 (8.3%) View
LuxC (PF05893) 358 (0.7%) View
DUF1487 (PF07368) 111 (0.2%) View
Total: 4 Total: 48240 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
Histidinol_dh Histidinol_dh
Aldedh Aldedh

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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