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539  structures 4717  species 11  interactions 24927  sequences 313  architectures

Clan: Gal_mutarotase (CL0103)

Summary

Galactose Mutarotase-like superfamily Add an annotation

This clan is composed of a beta-sandwich that was first observed in domain 5 of beta-galactosidase, then as the central domain of copper amine oxidase, the C-terminal domain of chondroitinase, the C-terminal domain of hyaluronate lyase, the N-terminal domain of maltose phosphorylase and in Galactose Mutarotase [1]. All these enzymes act on a sugar substrate.

This clan contains 11 families and the total number of domains in the clan is 24927. The clan was built by A Bateman.

Literature references

  1. Thoden JB, Holden HM; , J Biol Chem 2002;277:20854-20861.: High resolution X-ray structure of galactose mutarotase from Lactococcus lactis. PUBMED:11907040 EPMC:11907040

Members

This clan contains the following 11 member families:

Aldose_epim Bgal_small_N DUF4432 Gal_mutarotas_2 Glyco_hyd_65N_2 Glyco_hydro_38C Glyco_hydro_65N Lyase_8 MdoG Rhamnogal_lyase YidC_periplas

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Aldose_epim (PF01263) 8201 (32.9%) View
Gal_mutarotas_2 (PF13802) 2671 (10.7%) View
Glyco_hydro_38C (PF07748) 2571 (10.3%) View
Bgal_small_N (PF02929) 2500 (10.0%) View
YidC_periplas (PF14849) 2338 (9.4%) View
Glyco_hydro_65N (PF03636) 1768 (7.1%) View
MdoG (PF04349) 1625 (6.5%) View
Glyco_hyd_65N_2 (PF14498) 1312 (5.3%) View
Lyase_8 (PF02278) 1067 (4.3%) View
DUF4432 (PF14486) 706 (2.8%) View
Rhamnogal_lyase (PF06045) 168 (0.7%) View
Total: 11 Total: 24927 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 11 interactions for this clan. More...

Interacting families
A B
MdoG MdoG
Aldose_epim Aldose_epim
Epimerase
Bgal_small_N Glyco_hydro_2_C
Glyco_hydro_2_N
Bgal_small_N
Glyco_hydro_38C Glyco_hydro_38
Alpha-mann_mid
Lyase_8 Lyase_8_C
Lyase_8_N
Lyase_catalyt

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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