Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
363  structures 4720  species 2  interactions 43346  sequences 157  architectures

Clan: Glyoxalase (CL0104)

Summary

VOC superfamily Add an annotation

This clan contains the VOC metalloenzyme superfamily [1]. The known types of reactions that are catalysed include isomerizations (glyoxalase I), epimerizations (methylmalonyl-CoA epimerase), oxidative cleavage of C-C bonds (extradiol dioxygenase), and nucleophilic substitutions (fosfomycin resistance proteins) [1].

This clan contains 8 families and the total number of domains in the clan is 43346. The clan was built by A Bateman.

Literature references

  1. Armstrong RN; , Biochemistry 2000;39:13625-13632.: Mechanistic diversity in a metalloenzyme superfamily. PUBMED:11076500 EPMC:11076500

Members

This clan contains the following 8 member families:

3-dmu-9_3-mt CppA_N Glyoxalase Glyoxalase_2 Glyoxalase_3 Glyoxalase_4 Glyoxalase_5 YecM

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Glyoxalase_2 (PF12681) 20226 (46.7%) View
Glyoxalase (PF00903) 14717 (34.0%) View
3-dmu-9_3-mt (PF06983) 2984 (6.9%) View
Glyoxalase_4 (PF13669) 2150 (5.0%) View
Glyoxalase_5 (PF14696) 1091 (2.5%) View
Glyoxalase_3 (PF13468) 1009 (2.3%) View
YecM (PF06185) 775 (1.8%) View
CppA_N (PF14506) 394 (0.9%) View
Total: 8 Total: 43346 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls

Hide

This tree shows the occurrence of the domains in this clan across different species. More...

Loading...

Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
3-dmu-9_3-mt 3-dmu-9_3-mt
Glyoxalase Glyoxalase

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...