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713  structures 7680  species 17  interactions 127750  sequences 1496  architectures

Clan: GT-A (CL0110)

Summary

Glycosyl transferase clan GT-A Add an annotation

This is the GT-A clan that contains diverse glycosyltransferases that possess a Rossmann like fold [1].

This clan contains 44 families and the total number of domains in the clan is 127750. The clan was built by A Bateman.

Literature references

  1. Liu J, Mushegian A; , Protein Sci 2003;12:1418-1431.: Three monophyletic superfamilies account for the majority of the known glycosyltransferases. PUBMED:12824488 EPMC:12824488

Members

This clan contains the following 44 member families:

Anp1 Caps_synth Cellulose_synt CgtA CHGN Chitin_synth_1 Chitin_synth_2 CofC CTP_transf_3 DUF2064 DUF273 DUF604 Fringe Galactosyl_T GlcNAc Gly_transf_sug Glyco_tranf_2_2 Glyco_tranf_2_3 Glyco_tranf_2_4 Glyco_tranf_2_5 Glyco_trans_2_3 Glyco_transf_21 Glyco_transf_25 Glyco_transf_34 Glyco_transf_43 Glyco_transf_49 Glyco_transf_6 Glyco_transf_64 Glyco_transf_7C Glyco_transf_7N Glyco_transf_8 Glyco_transf_92 Glycos_transf_2 GNT-I IspD Mannosyl_trans3 MGAT2 NTP_transf_3 NTP_transferase Nucleotid_trans Pox_P35 Rhamno_transf TcdA_TcdB UDPGP

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Glycos_transf_2 (PF00535) 43678 (34.2%) View
NTP_transferase (PF00483) 22811 (17.9%) View
NTP_transf_3 (PF12804) 9345 (7.3%) View
Glyco_tranf_2_3 (PF13641) 8712 (6.8%) View
Glyco_transf_8 (PF01501) 5748 (4.5%) View
IspD (PF01128) 4492 (3.5%) View
CTP_transf_3 (PF02348) 4289 (3.4%) View
Glyco_trans_2_3 (PF13632) 2553 (2.0%) View
Galactosyl_T (PF01762) 2182 (1.7%) View
Glyco_transf_25 (PF01755) 1865 (1.5%) View
Gly_transf_sug (PF04488) 1796 (1.4%) View
UDPGP (PF01704) 1651 (1.3%) View
Cellulose_synt (PF03552) 1407 (1.1%) View
Glyco_transf_7C (PF02709) 1328 (1.0%) View
Chitin_synth_2 (PF03142) 1072 (0.8%) View
Fringe (PF02434) 1045 (0.8%) View
Glyco_tranf_2_4 (PF13704) 934 (0.7%) View
Chitin_synth_1 (PF01644) 884 (0.7%) View
Glyco_transf_92 (PF01697) 812 (0.6%) View
Glyco_transf_7N (PF13733) 775 (0.6%) View
Glyco_transf_49 (PF13896) 771 (0.6%) View
Mannosyl_trans3 (PF11051) 725 (0.6%) View
Nucleotid_trans (PF03407) 713 (0.6%) View
continued
Pfam family Num. domains Alignment
Glyco_transf_21 (PF13506) 703 (0.6%) View
CHGN (PF05679) 643 (0.5%) View
Glyco_transf_64 (PF09258) 640 (0.5%) View
Glyco_transf_34 (PF05637) 639 (0.5%) View
Glyco_transf_6 (PF03414) 613 (0.5%) View
Glyco_transf_43 (PF03360) 602 (0.5%) View
DUF2064 (PF09837) 550 (0.4%) View
Glyco_tranf_2_2 (PF10111) 436 (0.3%) View
Anp1 (PF03452) 428 (0.3%) View
Caps_synth (PF05704) 400 (0.3%) View
TcdA_TcdB (PF12919) 376 (0.3%) View
GNT-I (PF03071) 372 (0.3%) View
Glyco_tranf_2_5 (PF13712) 312 (0.2%) View
DUF604 (PF04646) 290 (0.2%) View
CofC (PF01983) 277 (0.2%) View
GlcNAc (PF11397) 216 (0.2%) View
MGAT2 (PF05060) 200 (0.2%) View
CgtA (PF06306) 149 (0.1%) View
Pox_P35 (PF03213) 130 (0.1%) View
Rhamno_transf (PF11316) 99 (0.1%) View
DUF273 (PF03314) 87 (0.1%) View
Total: 44 Total: 127750 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

We could not retrieve a family relationship diagram for this clan.

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 17 interactions for this clan. More...

Interacting families
A B
Glyco_transf_64 Glyco_transf_64
IspD Hexapep
IspD
YgbB
Glycos_transf_2 Ricin_B_lectin
Glyco_transf_34 Glyco_transf_34
Glyco_transf_7C Lys
Glyco_transf_7C
UDPGP UDPGP
NTP_transferase Hexapep
NTP_transferase
MannoseP_isomer
Glyco_transf_43 Glyco_transf_43
CofC CofC
Glyco_transf_8 Glyco_transf_8
CTP_transf_3 CTP_transf_3
Glyco_transf_6 Glyco_transf_6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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