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662  structures 3233  species 4  interactions 10920  sequences 102  architectures

Clan: Calycin (CL0116)

Summary

Calycin superfamily Add an annotation

The calycin structural superfamily [1-3] includes the lipocalins, the fatty acid-binding proteins (FABPs).

This clan contains 16 families and the total number of domains in the clan is 10920. The clan was built by A Bateman.

Literature references

  1. Flower DR, North AC, Sansom CE; , Biochim Biophys Acta 2000;1482:9-24.: The lipocalin protein family: structural and sequence overview. PUBMED:11058743 EPMC:11058743
  2. Flower DR; , FEBS Lett 1993;333:99-102.: Structural relationship of streptavidin to the calycin protein superfamily. PUBMED:8224179 EPMC:8224179
  3. Flower DR, North AC, Attwood TK; , Protein Sci 1993;2:753-761.: Structure and sequence relationships in the lipocalins and related proteins. PUBMED:7684291 EPMC:7684291

Members

This clan contains the following 16 member families:

ApoM DUF3642 His_binding Lipocalin Lipocalin_2 Lipocalin_3 Lipocalin_4 Lipocalin_5 Lipocalin_6 Lipocalin_7 META Nitrophorin NlpE Triabin VDE YodA

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Lipocalin (PF00061) 2221 (20.3%) View
META (PF03724) 2207 (20.2%) View
Lipocalin_2 (PF08212) 1931 (17.7%) View
YodA (PF09223) 1239 (11.3%) View
NlpE (PF04170) 993 (9.1%) View
Lipocalin_4 (PF13648) 502 (4.6%) View
His_binding (PF02098) 345 (3.2%) View
Triabin (PF03973) 329 (3.0%) View
DUF3642 (PF12182) 315 (2.9%) View
Lipocalin_5 (PF13924) 249 (2.3%) View
Lipocalin_7 (PF14651) 209 (1.9%) View
Lipocalin_6 (PF13944) 111 (1.0%) View
VDE (PF07137) 98 (0.9%) View
Lipocalin_3 (PF12702) 79 (0.7%) View
ApoM (PF11032) 77 (0.7%) View
Nitrophorin (PF02087) 15 (0.1%) View
Total: 16 Total: 10920 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 4 interactions for this clan. More...

Interacting families
A B
Lipocalin Lipocalin
His_binding His_binding
Lipocalin_2 Lipocalin_2
Nitrophorin Nitrophorin

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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