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34  structures 768  species 3  interactions 5476  sequences 59  architectures

Clan: Arrestin_N-like (CL0135)

Summary

Arrestin_N-like Add an annotation

The families in this clan are involved in vacuolar protein trafficking, G protein signal termination and sporulation. The Arrestin N terminal domain has an Ig-like beta sandwich fold which binds to receptors and impairs their capacity to active G proteins [1]. Arrestins have also been implicated in the endocytosis of receptors and cross talk with other signalling pathways [2].

This clan contains 6 families and the total number of domains in the clan is 5476. The clan was built by J Mistry.

Literature references

  1. Granzin J, Wilden U, Choe HW, Labahn J, Krafft B, Buldt G; , Nature 1998;391:918-921.: X-ray crystal structure of arrestin from bovine rod outer segments. PUBMED:9495348 EPMC:9495348
  2. Claing A, Laporte SA, Caron MG, Lefkowitz RJ; , Prog Neurobiol 2002;66:61-79.: Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins. PUBMED:11900882 EPMC:11900882
  3. Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI; , Mol Biol Cell 2000;11:4105-4116.: Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. PUBMED:11102511 EPMC:11102511
  4. Han WD, Kawamoto S, Hosoya Y, Fujita M, Sadaie Y, Suzuki K, Ohashi Y, Kawamura F, Ochi K; , Gene 1998;217:31-40.: A novel sporulation-control gene (spo0M) of Bacillus subtilis with a sigmaH-regulated promoter. PUBMED:9795118 EPMC:9795118

Members

This clan contains the following 6 member families:

Arrestin_C Arrestin_N Bul1_N LDB19 Spo0M Vps26

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Arrestin_N (PF00339) 2044 (37.3%) View
Arrestin_C (PF02752) 1981 (36.2%) View
Vps26 (PF03643) 653 (11.9%) View
Spo0M (PF07070) 513 (9.4%) View
Bul1_N (PF04425) 164 (3.0%) View
LDB19 (PF13002) 121 (2.2%) View
Total: 6 Total: 5476 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 3 interactions for this clan. More...

Interacting families
A B
Arrestin_C Arrestin_N
Arrestin_C
Arrestin_N Arrestin_C

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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