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1072  structures 6497  species 63  interactions 213896  sequences 9593  architectures

Clan: E-set (CL0159)

Summary

Ig-like fold superfamily (E-set) Add an annotation

This clan includes a diverse range of domains that have an Ig-like fold and appear to be distantly related to each other. The clan includes: PKD domains, cadherins and several families of bacterial Ig-like domains as well as viral tail fibre proteins. it also includes several Fibronectin type III domain-containing families.

This clan contains 63 families and the total number of domains in the clan is 213896. The clan was built by RD Finn and A Bateman.

Members

This clan contains the following 63 member families:

A2M_N Alpha_adaptinC2 Big_1 Big_2 Big_3 Big_3_2 Big_3_3 Big_3_4 Big_4 Big_5 BiPBP_C BsuPI Cadherin Cadherin-like Cadherin_2 Cadherin_pro CARDB CHB_HEX_C CHB_HEX_C_1 ChitinaseA_N CHU_C Coatamer_beta_C COP-gamma_platf CopC DUF1034 DUF11 DUF1973 DUF2271 DUF4165 DUF4625 DUF916 EpoR_lig-bind Filamin FixG_C FlgD_ig fn3 Fn3_assoc He_PIG HYR IFNGR1 IL6Ra-bind Integrin_alpha2 Interfer-bind Invasin_D3 MG1 Mo-co_dimer Neurexophilin NPCBM_assoc PapD_N PKD PPC Qn_am_d_aIII REJ Rib SoxZ SprB SWM_repeat T2SS-T3SS_pil_N TIG Tissue_fac Transglut_C TRAP_beta Y_Y_Y

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
fn3 (PF00041) 58087 (27.2%) View
Cadherin (PF00028) 41902 (19.6%) View
TIG (PF01833) 8379 (3.9%) View
Filamin (PF00630) 7961 (3.7%) View
PapD_N (PF00345) 7954 (3.7%) View
Big_3_4 (PF13754) 7056 (3.3%) View
DUF11 (PF01345) 6559 (3.1%) View
Big_2 (PF02368) 5992 (2.8%) View
Big_1 (PF02369) 5706 (2.7%) View
PKD (PF00801) 5437 (2.5%) View
SWM_repeat (PF13753) 4913 (2.3%) View
Y_Y_Y (PF07495) 2976 (1.4%) View
A2M_N (PF01835) 2926 (1.4%) View
Mo-co_dimer (PF03404) 2673 (1.2%) View
Cadherin_2 (PF08266) 2331 (1.1%) View
Big_3 (PF07523) 2232 (1.0%) View
He_PIG (PF05345) 2176 (1.0%) View
PPC (PF04151) 2040 (1.0%) View
FlgD_ig (PF13860) 1909 (0.9%) View
Big_4 (PF07532) 1839 (0.9%) View
HYR (PF02494) 1816 (0.8%) View
Big_3_2 (PF12245) 1694 (0.8%) View
CopC (PF04234) 1651 (0.8%) View
Rib (PF08428) 1574 (0.7%) View
Big_5 (PF13205) 1557 (0.7%) View
Integrin_alpha2 (PF08441) 1499 (0.7%) View
Alpha_adaptinC2 (PF02883) 1431 (0.7%) View
CARDB (PF07705) 1259 (0.6%) View
CHB_HEX_C (PF03174) 1239 (0.6%) View
BiPBP_C (PF06832) 1158 (0.5%) View
FixG_C (PF11614) 1156 (0.5%) View
CHU_C (PF13585) 1085 (0.5%) View
continued
Pfam family Num. domains Alignment
MG1 (PF11974) 1084 (0.5%) View
REJ (PF02010) 1075 (0.5%) View
Transglut_C (PF00927) 1042 (0.5%) View
T2SS-T3SS_pil_N (PF13629) 1023 (0.5%) View
SprB (PF13573) 1000 (0.5%) View
DUF916 (PF06030) 922 (0.4%) View
DUF1034 (PF06280) 863 (0.4%) View
Tissue_fac (PF01108) 788 (0.4%) View
Interfer-bind (PF09294) 681 (0.3%) View
Cadherin-like (PF12733) 661 (0.3%) View
NPCBM_assoc (PF10633) 604 (0.3%) View
IL6Ra-bind (PF09240) 523 (0.2%) View
EpoR_lig-bind (PF09067) 520 (0.2%) View
Neurexophilin (PF06312) 508 (0.2%) View
SoxZ (PF08770) 444 (0.2%) View
COP-gamma_platf (PF08752) 438 (0.2%) View
Cadherin_pro (PF08758) 421 (0.2%) View
ChitinaseA_N (PF08329) 378 (0.2%) View
DUF2271 (PF10029) 357 (0.2%) View
Coatamer_beta_C (PF07718) 351 (0.2%) View
DUF1973 (PF09315) 287 (0.1%) View
Fn3_assoc (PF13287) 282 (0.1%) View
Invasin_D3 (PF09134) 269 (0.1%) View
TRAP_beta (PF05753) 254 (0.1%) View
CHB_HEX_C_1 (PF13290) 225 (0.1%) View
Big_3_3 (PF13750) 166 (0.1%) View
BsuPI (PF12690) 149 (0.1%) View
DUF4625 (PF15418) 136 (0.1%) View
IFNGR1 (PF07140) 134 (0.1%) View
DUF4165 (PF13752) 99 (0.0%) View
Qn_am_d_aIII (PF09099) 45 (0.0%) View
Total: 63 Total: 213896 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

We could not retrieve a family relationship diagram for this clan.

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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