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40  structures 2883  species 3  interactions 12801  sequences 407  architectures

Clan: Cache (CL0165)

Summary

Cache-like domain Add an annotation

The Cache domain an extracellular domain that is thought to have a role in small-molecule recognition in a wide range of proteins, including the animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors [1].

This clan contains 6 families and the total number of domains in the clan is 12801. The clan was built by RD Finn.

Literature references

  1. Anantharaman V, Aravind L; , Trends Biochem Sci 2000;25:535-537.: Cache - a signaling domain common to animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors. PUBMED:11084361 EPMC:11084361

Members

This clan contains the following 6 member families:

Cache_1 Cache_2 Cache_3 DUF4153 DUF4173 YkuI_C

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Cache_1 (PF02743) 6574 (51.4%) View
Cache_3 (PF14827) 2633 (20.6%) View
Cache_2 (PF08269) 2356 (18.4%) View
DUF4153 (PF13687) 732 (5.7%) View
YkuI_C (PF10388) 277 (2.2%) View
DUF4173 (PF13777) 229 (1.8%) View
Total: 6 Total: 12801 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 3 interactions for this clan. More...

Interacting families
A B
Cache_2 Cache_2
YkuI_C EAL
YkuI_C

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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