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397  structures 7468  species 24  interactions 61819  sequences 518  architectures

Clan: ATP-grasp (CL0179)

Summary

ATP-grasp superfamily Add an annotation

The ATP-grasp domain is found in a wide variety of carboxylate-amine/thiol ligases [1]. It is composed of two subdomains, with ATP being bound in the cleft between the two.

This clan contains 20 families and the total number of domains in the clan is 61819. The clan was built by A Bateman.

Literature references

  1. Galperin MY, Koonin EV; , Protein Sci 1997;6:2639-2643.: A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity. PUBMED:9416615 EPMC:9416615

Members

This clan contains the following 20 member families:

ATP-grasp ATP-grasp_2 ATP-grasp_3 ATP-grasp_4 ATP-grasp_5 ATPgrasp_ST ATPgrasp_Ter ATPgrasp_TupA ATPgrasp_YheCD CP_ATPgrasp_1 CP_ATPgrasp_2 CPSase_L_D2 Dala_Dala_lig_C DUF1297 GARS_A GSH-S_ATP Ins134_P3_kin RimK Synapsin_C TTL

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CPSase_L_D2 (PF02786) 23031 (37.3%) View
Dala_Dala_lig_C (PF07478) 6597 (10.7%) View
ATP-grasp (PF02222) 5314 (8.6%) View
ATP-grasp_4 (PF13535) 4886 (7.9%) View
GARS_A (PF01071) 4769 (7.7%) View
ATP-grasp_2 (PF08442) 4398 (7.1%) View
RimK (PF08443) 2606 (4.2%) View
TTL (PF03133) 2286 (3.7%) View
ATP-grasp_5 (PF13549) 2119 (3.4%) View
GSH-S_ATP (PF02955) 1779 (2.9%) View
CP_ATPgrasp_1 (PF04174) 1353 (2.2%) View
ATPgrasp_YheCD (PF14398) 572 (0.9%) View
ATPgrasp_ST (PF14397) 400 (0.6%) View
ATPgrasp_TupA (PF14305) 355 (0.6%) View
ATP-grasp_3 (PF02655) 304 (0.5%) View
Synapsin_C (PF02750) 298 (0.5%) View
Ins134_P3_kin (PF05770) 297 (0.5%) View
ATPgrasp_Ter (PF15632) 206 (0.3%) View
DUF1297 (PF06973) 191 (0.3%) View
CP_ATPgrasp_2 (PF14403) 58 (0.1%) View
Total: 20 Total: 61819 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 24 interactions for this clan. More...

Interacting families
A B
ATP-grasp ATP-grasp
CPSase_L_D2 GATase
CPSase_L_chain
CPSase_sm_chain
MGS
Biotin_carb_C
CPSase_L_D2
CPSase_L_D3
GSH-S_ATP GSH-S_N
GSH-S_ATP
DUF1297 DUF1246
DUF1297
GARS_A GARS_A
GARS_C
GARS_N
Dala_Dala_lig_C Dala_Dala_lig_N
Dala_Dala_lig_C
Synapsin_C Synapsin
Synapsin_C
ATP-grasp_3 ATP-grasp_3
ATP-grasp_2 Ligase_CoA
CoA_binding
ATP-grasp_2
Ins134_P3_kin Ins134_P3_kin

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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