Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
195  structures 2847  species 2  interactions 5166  sequences 41  architectures

Clan: HO (CL0230)

Summary

Heme oxygenase-like superfamily Add an annotation

This clan includes the Heme oxygenase family as well as the TENA/THI-4/PQQC family that are less well characterised [2].

This clan contains 5 families and the total number of domains in the clan is 5166. The clan was built by A Bateman.

Literature references

  1. Benach J, Edstrom WC, Lee I, Das K, Cooper B, Xiao R, Liu J, Rost B, Acton TB, Montelione GT, Hunt JF; , Acta Crystallogr D Biol Crystallogr. 2005;61:589-598.: The 2.35 A structure of the TenA homolog from Pyrococcus furiosus supports an enzymatic function in thiamine metabolism. PUBMED:15858269 EPMC:15858269
  2. Schuller DJ, Wilks A, Ortiz de Montellano PR, Poulos TL; , Nat Struct Biol. 1999;6:860-867.: Crystal structure of human heme oxygenase-1. PUBMED:10467099 EPMC:10467099

Members

This clan contains the following 5 member families:

DUF3050 DUF3865 Haem_oxygenas_2 Heme_oxygenase TENA_THI-4

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TENA_THI-4 (PF03070) 3227 (62.5%) View
Heme_oxygenase (PF01126) 1215 (23.5%) View
Haem_oxygenas_2 (PF14518) 559 (10.8%) View
DUF3050 (PF11251) 145 (2.8%) View
DUF3865 (PF12981) 20 (0.4%) View
Total: 5 Total: 5166 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls

Hide

This tree shows the occurrence of the domains in this clan across different species. More...

Loading...

Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
Heme_oxygenase Heme_oxygenase
TENA_THI-4 TENA_THI-4

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...