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146  structures 5088  species 2  interactions 20115  sequences 173  architectures

Clan: PFK (CL0240)

Summary

PFK-like superfamily Add an annotation

This clan includes two SCOP superfamilies. Strong similarities between NAD kinases, DAG kinase, sphingosine kinase and PFK have previously been shown[1].

This clan contains 3 families and the total number of domains in the clan is 20115. The clan was built by A Bateman.

Literature references

  1. Labesse G, Douguet D, Assairi L, Gilles AM; , Trends Biochem Sci. 2002;27:273-275.: Diacylglyceride kinases, sphingosine kinases and NAD kinases: distant relatives of 6-phosphofructokinases. PUBMED:12069781 EPMC:12069781

Members

This clan contains the following 3 member families:

DAGK_cat NAD_kinase PFK

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DAGK_cat (PF00781) 7254 (36.1%) View
PFK (PF00365) 6795 (33.8%) View
NAD_kinase (PF01513) 6066 (30.2%) View
Total: 3 Total: 20115 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
PFK PFK
NAD_kinase NAD_kinase

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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