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419  structures 2586  species 17  interactions 41992  sequences 1526  architectures

Clan: PH (CL0266)

Summary

PH domain-like superfamily Add an annotation

Members of this clan share a PH-like fold. Many families in this clan bind to short peptide motifs in proteins and are involved in signalling.

This clan contains 33 families and the total number of domains in the clan is 41992. The clan was built by A Bateman.

Members

This clan contains the following 33 member families:

bPH_1 bPH_2 bPH_3 bPH_4 bPH_5 bPH_6 DCP1 DUF1448 FERM_C GRAM ICAP-1_inte_bdg Mcp5_PH PH PH_10 PH_11 PH_2 PH_3 PH_4 PH_5 PH_6 PH_7 PH_8 PH_9 PH_BEACH PID PID_2 PTB Ran_BP1 Rtt106 SSrecog Voldacs Vps36_ESCRT-II WH1

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PH (PF00169) 16347 (38.9%) View
bPH_2 (PF03703) 4794 (11.4%) View
PID (PF00640) 2909 (6.9%) View
GRAM (PF02893) 2555 (6.1%) View
FERM_C (PF09380) 2452 (5.8%) View
Ran_BP1 (PF00638) 1512 (3.6%) View
WH1 (PF00568) 1177 (2.8%) View
PH_9 (PF15410) 917 (2.2%) View
PH_BEACH (PF14844) 917 (2.2%) View
Rtt106 (PF08512) 861 (2.1%) View
bPH_1 (PF08000) 796 (1.9%) View
bPH_6 (PF10756) 695 (1.7%) View
bPH_3 (PF14470) 691 (1.6%) View
PTB (PF08416) 631 (1.5%) View
PH_8 (PF15409) 458 (1.1%) View
bPH_4 (PF06713) 441 (1.1%) View
DCP1 (PF06058) 430 (1.0%) View
continued
Pfam family Num. domains Alignment
SSrecog (PF03531) 417 (1.0%) View
Voldacs (PF03517) 359 (0.9%) View
Mcp5_PH (PF12814) 320 (0.8%) View
bPH_5 (PF10882) 319 (0.8%) View
PH_5 (PF15405) 284 (0.7%) View
PH_11 (PF15413) 262 (0.6%) View
PH_10 (PF15411) 249 (0.6%) View
Vps36_ESCRT-II (PF11605) 246 (0.6%) View
PH_3 (PF14593) 202 (0.5%) View
PID_2 (PF14719) 195 (0.5%) View
DUF1448 (PF07289) 172 (0.4%) View
PH_2 (PF08458) 142 (0.3%) View
PH_4 (PF15404) 91 (0.2%) View
ICAP-1_inte_bdg (PF10480) 77 (0.2%) View
PH_6 (PF15406) 72 (0.2%) View
PH_7 (PF15408) 2 (0.0%) View
Total: 33 Total: 41992 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 17 interactions for this clan. More...

Interacting families
A B
PID PID
PH SH3_1
Ras
PH
WD40
RhoGEF
Sec7
IRS
SSrecog SSrecog
PTB PTB
DCP1 DCP1
Ran_BP1 Ras
Vps36_ESCRT-II ubiquitin
Vps36_ESCRT-II
FERM_C FERM_M
FERM_N
FERM_C

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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