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323  structures 6496  species 4  interactions 27220  sequences 67  architectures

Clan: Iso_DH (CL0270)

Summary

Isocitrate/Isopropylmalate dehydrogenase-like superfamily Add an annotation

This superfamily of enzymes form dimers and have an active site between the two halves.

This clan contains 5 families and the total number of domains in the clan is 27220. The clan was built by A Bateman.

Literature references

  1. Sivaraman J, Li Y, Banks J, Cane DE, Matte A, Cygler M; , J Biol Chem. 2003;278:43682-43690.: Crystal structure of Escherichia coli PdxA, an enzyme involved in the pyridoxal phosphate biosynthesis pathway. PUBMED:12896974 EPMC:12896974
  2. Iyer PP, Lawrence SH, Luther KB, Rajashankar KR, Yennawar HP, Ferry JG, Schindelin H; , Structure. 2004;12:559-567.: Crystal structure of phosphotransacetylase from the methanogenic archaeon Methanosarcina thermophila. PUBMED:15062079 EPMC:15062079

Members

This clan contains the following 5 member families:

FA_synthesis IDH Iso_dh PdxA PTA_PTB

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Iso_dh (PF00180) 12354 (45.4%) View
PTA_PTB (PF01515) 7061 (25.9%) View
FA_synthesis (PF02504) 3673 (13.5%) View
PdxA (PF04166) 2867 (10.5%) View
IDH (PF03971) 1265 (4.6%) View
Total: 5 Total: 27220 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 4 interactions for this clan. More...

Interacting families
A B
PdxA PdxA
PTA_PTB PTA_PTB
IDH IDH
Iso_dh Iso_dh

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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