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289  structures 5430  species 7  interactions 13968  sequences 53  architectures

Clan: H2TH (CL0303)

Summary

Helix-two-turns-helix superfamily Add an annotation

This domain is thought to play a role in binding nucleic acids. It is DNA binding in nucleases and RNA-binding in ribosomal S13.

This clan contains 3 families and the total number of domains in the clan is 13968. The clan was built by A Bateman.

Members

This clan contains the following 3 member families:

FbpA H2TH Ribosomal_S13

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Ribosomal_S13 (PF00416) 5791 (41.5%) View
H2TH (PF06831) 5357 (38.4%) View
FbpA (PF05833) 2820 (20.2%) View
Total: 3 Total: 13968 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 7 interactions for this clan. More...

Interacting families
A B
FbpA HATPase_c
FbpA
Topo-VIb_trans
H2TH Fapy_DNA_glyco
zf-FPG_IleRS
H2TH
Neil1-DNA_bind

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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