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241  structures 2337  species 3  interactions 328673  sequences 8637  architectures

Clan: C2H2-zf (CL0361)

Summary

Classical C2H2 and C2HC zinc fingers Add an annotation

Superfamily of classical and closely related C2H2 or beta-beta-alpha zinc finger DNA-binding domains.

This clan contains 19 families and the total number of domains in the clan is 328673. The clan was built by P Coggill.

Members

This clan contains the following 19 member families:

4F5 DUF3449 GAGA Sgf11 zf-AD zf-BED zf-C2H2 zf-C2H2_2 zf-C2H2_4 zf-C2H2_6 zf-C2H2_7 zf-C2H2_jaz zf-C2HC_2 zf-Di19 zf-H2C2_2 zf-H2C2_5 zf-met zf-met2 zf-U1

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
zf-H2C2_2 (PF13465) 227898 (69.3%) View
zf-C2H2 (PF00096) 44392 (13.5%) View
zf-C2H2_4 (PF13894) 26727 (8.1%) View
zf-C2H2_6 (PF13912) 8615 (2.6%) View
zf-met (PF12874) 5348 (1.6%) View
zf-H2C2_5 (PF13909) 3546 (1.1%) View
zf-AD (PF07776) 2455 (0.7%) View
zf-C2H2_2 (PF12756) 2196 (0.7%) View
zf-C2H2_jaz (PF12171) 2095 (0.6%) View
zf-BED (PF02892) 1403 (0.4%) View
zf-C2HC_2 (PF13913) 1078 (0.3%) View
zf-Di19 (PF05605) 760 (0.2%) View
zf-U1 (PF06220) 661 (0.2%) View
4F5 (PF04419) 536 (0.2%) View
DUF3449 (PF11931) 347 (0.1%) View
zf-met2 (PF12907) 251 (0.1%) View
Sgf11 (PF08209) 238 (0.1%) View
zf-C2H2_7 (PF15269) 69 (0.0%) View
GAGA (PF09237) 58 (0.0%) View
Total: 19 Total: 328673 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 3 interactions for this clan. More...

Interacting families
A B
zf-AD zf-AD
zf-C2H2 zf-C2H2
GATA

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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