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184  structures 1231  species 3  interactions 20485  sequences 1096  architectures

Clan: zf-FYVE-PHD (CL0390)

Summary

FYVE/PHD zinc finger superfamily Add an annotation

Superfamily contains a number of zinc-fingers, of the FYVE/PHD type, which are found in several groups of proteins including myelin-associated oligodendrocytic basic proteins (MOBP) Rabphilins, melanophilins, exophilins and myosin-VIIA and Rab-interacting protein families.

This clan contains 9 families and the total number of domains in the clan is 20485. The clan was built by P Coggill.

Members

This clan contains the following 9 member families:

FYVE FYVE_2 PHD PHD_2 RAG2_PHD zf-HC5HC2H zf-HC5HC2H_2 zf-PHD-like zf-piccolo

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PHD (PF00628) 10006 (48.8%) View
FYVE (PF01363) 4289 (20.9%) View
zf-HC5HC2H_2 (PF13832) 1557 (7.6%) View
PHD_2 (PF13831) 1358 (6.6%) View
zf-HC5HC2H (PF13771) 1247 (6.1%) View
RAG2_PHD (PF13341) 1007 (4.9%) View
FYVE_2 (PF02318) 739 (3.6%) View
zf-piccolo (PF05715) 212 (1.0%) View
zf-PHD-like (PF15446) 70 (0.3%) View
Total: 9 Total: 20485 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 3 interactions for this clan. More...

Interacting families
A B
PHD PHD
FYVE VHS
FYVE

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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