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5  structures 475  species 0  interactions 1960  sequences 10  architectures

Clan: GG-leader (CL0400)

Summary

Double-Glycine leader-peptide cleavage motif Add an annotation

This is a collection of short bacterial families that carry a distinctive GG-cleavage motif. Conservation C-terminal to the GG-motif is not apparent. However, the families are all interconnected with critical virulence attributes of one kind or another.

This clan contains 5 families and the total number of domains in the clan is 1960. The clan was built by P Coggill.

Members

This clan contains the following 5 member families:

Antimicrobial17 Bacteriocin_IIc ComC L_biotic_typeA Lactococcin

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Bacteriocin_IIc (PF10439) 1162 (59.3%) View
ComC (PF03047) 666 (34.0%) View
L_biotic_typeA (PF04604) 102 (5.2%) View
Lactococcin (PF04369) 23 (1.2%) View
Antimicrobial17 (PF08129) 7 (0.4%) View
Total: 5 Total: 1960 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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