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387  structures 30583  species 1  interaction 37487  sequences 191  architectures

Clan: Sialidase (CL0434)


Sialidase superfamily Add an annotation

This superfamily includes sialidases enzymes. Several viruses use sialic acid as a cell surface receptor for host invasion. These viruses then have cell surface neuraminidase enzymes to cleave sialic acid from cell surface proteins allowing them to leave the host cell after replication. This superfamily are composed of six beta-sheets that form a six-fold beta-propeller structure. Many members of this superfamily contain BNR sequence motifs Pfam:PF02012.

This clan contains 7 families and the total number of domains in the clan is 37487. The clan was built by A Bateman.

Literature references

  1. Taylor G;, Curr Opin Struct Biol. 1996;6:830-837.: Sialidases: structures, biological significance and therapeutic potential. PUBMED:8994884 EPMC:8994884


This clan contains the following 7 member families:

BNR BNR_2 BNR_3 End_beta_propel HN Neur PSII_BNR

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Neur (PF00064) 29236 (78.0%) View
BNR_2 (PF13088) 2868 (7.7%) View
HN (PF00423) 2456 (6.6%) View
BNR_3 (PF13859) 1305 (3.5%) View
BNR (PF02012) 830 (2.2%) View
PSII_BNR (PF14870) 762 (2.0%) View
End_beta_propel (PF12217) 30 (0.1%) View
Total: 7 Total: 37487 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There is 1 interaction for this clan. More...

Interacting families
BNR Kelch_1


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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