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215  structures 329  species 5  interactions 6504  sequences 445  architectures

Clan: Protease_inhib (CL0454)

Summary

Protease inhibitor toxin superfamily Add an annotation

This superfamily includes several families of toxins which seem to act as protease inuibitors.

This clan contains 2 families and the total number of domains in the clan is 6504. The clan was built by P Coggill.

Members

This clan contains the following 2 member families:

Kunitz_BPTI WAP

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Kunitz_BPTI (PF00014) 4915 (75.6%) View
WAP (PF00095) 1589 (24.4%) View
Total: 2 Total: 6504 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 5 interactions for this clan. More...

Interacting families
A B
WAP Trypsin
Kunitz_BPTI Kunitz_BPTI
Phospholip_A2_1
Trypsin
Peptidase_S7

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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