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32  structures 1652  species 2  interactions 2776  sequences 18  architectures

Clan: PreATP-grasp (CL0483)

Summary

Probable substrate-binding preceding ATP-grasp domain Add an annotation

This superfamily is characterised by bein g the copies of the domain that precedes the ATP-grasp domain common to all superfamily members, and it can contain a substrate-binding function.

This clan contains 2 families and the total number of domains in the clan is 2776. The clan was built by P Coggill.

Literature references

  1. Pai CH, Chiang BY, Ko TP, Chou CC, Chong CM, Yen FJ, Chen S, Coward JK, Wang AH, Lin CH;, EMBO J. 2006;25:5970-5982.: Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase. PUBMED:17124497 EPMC:17124497

Members

This clan contains the following 2 member families:

GSH_synthase GSP_synth

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GSP_synth (PF03738) 2307 (83.1%) View
GSH_synthase (PF03199) 469 (16.9%) View
Total: 2 Total: 2776 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
GSH_synthase GSH_synth_ATP
GSP_synth CHAP

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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