Summary
Tetratrico peptide repeat superfamily
Tetratricopeptide-like repeats are found in a numerous and diverse proteins involved in such functions as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding.
This clan contains 110 families and the total number of domains in the clan is 274874. The clan was built by DJ Studholme.
Literature references
- Lamb JR, Tugendreich S, Hieter P; , Trends Biochem Sci 1995;20:257-259.: Tetratrico peptide repeat interactions: to TPR or not to TPR? 7667876
- Das AK, Cohen PW, Barford D; , EMBO J 1998;17:1192-1199.: The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. 9482716
- Pallen MJ, Francis MS, Futterer K; , FEMS Microbiol Lett 2003;223:53-60.: Tetratricopeptide-like repeats in type-III-secretion chaperones and regulators. 12799000
- Rispal D, Henri J, van Tilbeurgh H, Graille M, Seraphin B;, RNA. 2011; [Epub ahead of print]: Structural and functional analysis of Nro1/Ett1: a protein involved in translation termination in S. cerevisiae and in O2-mediated gene control in S. pombe. 21610214
Members
This clan contains the following 110 member families:
Adaptin_N Apc3 Apc5 API5 Arm Arm_2 Avirulence BTAD CAS_CSE1 ChAPs CLASP_N Clathrin Clathrin-link Clathrin_propel Cnd1 Cnd3 Coatomer_E Cohesin_HEAT Cohesin_load CRM1_C Cse1 DNA_alkylation Drf_FH3 Drf_GBD DUF1822 DUF2225 DUF2435 DUF3385 DUF3458 DUF3808 DUF3856 EST1_DNA_bind FAT Foie-gras_1 GUN4 HAT HEAT HEAT_2 HEAT_EZ HEAT_PBS HemY_N IBB IBN_N IFRD KAP Leuk-A4-hydro_C LRV LRV_FeS MA3 MIF4G MIF4G_like MIF4G_like_2 Mo25 MRP-S27 NARP1 Neurochondrin Nro1 NSF Paf67 ParcG PC_rep PHAT PI3Ka PPP5 PPR PPR_1 PPR_2 PPR_3 Proteasom_PSMB PUF Rab5-bind Rapsyn_N RPN7 Sel1 SHNi-TPR SPO22 ST7 Suf SusD SusD-like SusD-like_2 SusD-like_3 Tcf25 TOM20_plant TPR_1 TPR_10 TPR_11 TPR_12 TPR_14 TPR_15 TPR_16 TPR_17 TPR_18 TPR_2 TPR_3 TPR_4 TPR_5 TPR_6 TPR_7 TPR_8 TPR_9 Upf2 V-ATPase_H_C V-ATPase_H_N Vac14_Fab1_bd Vitellogenin_N Vps39_1 W2 Xpo1 YfiOExternal database links
| CATH: | 1.25.40.10 |
| SCOP: | 48452 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
| Pfam family | Num. domains | Alignment |
|---|---|---|
| TPR_11 (PF13414) | 43998 (16.0%) | View |
| Sel1 (PF08238) | 28401 (10.3%) | View |
| PPR_2 (PF13041) | 24145 (8.8%) | View |
| PPR (PF01535) | 23916 (8.7%) | View |
| TPR_12 (PF13424) | 17251 (6.3%) | View |
| TPR_2 (PF07719) | 13034 (4.7%) | View |
| TPR_1 (PF00515) | 12829 (4.7%) | View |
| HEAT_2 (PF13646) | 8243 (3.0%) | View |
| TPR_16 (PF13432) | 7900 (2.9%) | View |
| Arm (PF00514) | 7087 (2.6%) | View |
| TPR_8 (PF13181) | 5789 (2.1%) | View |
| SusD (PF07980) | 5043 (1.8%) | View |
| SusD-like_3 (PF14322) | 4979 (1.8%) | View |
| TPR_6 (PF13174) | 4590 (1.7%) | View |
| PUF (PF00806) | 4584 (1.7%) | View |
| PPR_3 (PF13812) | 4434 (1.6%) | View |
| TPR_10 (PF13374) | 4092 (1.5%) | View |
| TPR_9 (PF13371) | 3659 (1.3%) | View |
| Clathrin (PF00637) | 2768 (1.0%) | View |
| Adaptin_N (PF01602) | 2566 (0.9%) | View |
| PPR_1 (PF12854) | 2508 (0.9%) | View |
| YfiO (PF13525) | 1874 (0.7%) | View |
| TPR_7 (PF13176) | 1856 (0.7%) | View |
| IBN_N (PF03810) | 1849 (0.7%) | View |
| MIF4G (PF02854) | 1662 (0.6%) | View |
| DNA_alkylation (PF08713) | 1593 (0.6%) | View |
| BTAD (PF03704) | 1559 (0.6%) | View |
| Apc3 (PF12895) | 1379 (0.5%) | View |
| DUF3458 (PF11940) | 1163 (0.4%) | View |
| HEAT_EZ (PF13513) | 1133 (0.4%) | View |
| HEAT (PF02985) | 1105 (0.4%) | View |
| MA3 (PF02847) | 1091 (0.4%) | View |
| HemY_N (PF07219) | 982 (0.4%) | View |
| Xpo1 (PF08389) | 923 (0.3%) | View |
| PC_rep (PF01851) | 897 (0.3%) | View |
| FAT (PF02259) | 845 (0.3%) | View |
| PI3Ka (PF00613) | 782 (0.3%) | View |
| CLASP_N (PF12348) | 753 (0.3%) | View |
| TPR_15 (PF13429) | 732 (0.3%) | View |
| W2 (PF02020) | 708 (0.3%) | View |
| Drf_GBD (PF06371) | 674 (0.2%) | View |
| TPR_3 (PF07720) | 665 (0.2%) | View |
| Avirulence (PF03377) | 651 (0.2%) | View |
| Vitellogenin_N (PF01347) | 650 (0.2%) | View |
| TPR_14 (PF13428) | 642 (0.2%) | View |
| TPR_17 (PF13431) | 564 (0.2%) | View |
| Drf_FH3 (PF06367) | 549 (0.2%) | View |
| SusD-like (PF12741) | 535 (0.2%) | View |
| IBB (PF01749) | 530 (0.2%) | View |
| RPN7 (PF10602) | 482 (0.2%) | View |
| KAP (PF05804) | 470 (0.2%) | View |
| SusD-like_2 (PF12771) | 437 (0.2%) | View |
| DUF2435 (PF10363) | 407 (0.1%) | View |
| Cse1 (PF08506) | 407 (0.1%) | View |
| Suf (PF05843) | 390 (0.1%) | View |
| EST1_DNA_bind (PF10373) | 389 (0.1%) | View |
| continued | ||
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Family relationships
This diagram shows the relationships between members of this clan. More...
We could not retrieve a family relationship diagram for this clan.
Species distribution
Tree controls
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Interactions
There are 72 interactions for this clan. More...
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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