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16  structures 4052  species 0  interactions 9025  sequences 91  architectures

Clan: Rhomboid-like (CL0207)

Summary

Integral membrane protein / protease Add an annotation

This clan contains proteins from both bacteria and eukaryotes. The Rhomboid protein is an intramembrane serine protease which is involved in epidermal growth factor (EGF)-dependent signalling pathways [1]. The DER1 family is involved in degradation of misfolded ER proteins [2].

This clan contains 3 families and the total number of domains in the clan is 9025. The clan was built by J Mistry.

Literature references

  1. Koonin EV, Makarova KS, Rogozin IB, Davidovic L, Letellier MC, Pellegrini L; , Genome Biol 2003;4:R19.: The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers. PUBMED:12620104 EPMC:12620104
  2. Knop M, Finger A, Braun T, Hellmuth K, Wolf DH; , EMBO J 1996;15:753-763.: Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast. PUBMED:8631297 EPMC:8631297

Members

This clan contains the following 3 member families:

DER1 DUF1751 Rhomboid

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Rhomboid (PF01694) 7854 (87.0%) View
DER1 (PF04511) 816 (9.0%) View
DUF1751 (PF08551) 355 (3.9%) View
Total: 3 Total: 9025 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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