Summary: Neurohypophysial hormones, C-terminal Domain

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Wikipedia: Neurohypophysial hormone
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Neurohypophysial hormone

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Neurohypophysial hormones, N-terminal Domain

crystal structure analysis of deamino-oxytocin. conformational flexibility and receptor binding

Identifiers

Symbol

Hormone_4

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	structure summary

Neurohypophysial hormones, C-terminal Domain

solution structure of the monomeric form of a mutant unliganded bovine neurophysin, minimized average structure

Identifiers

Symbol

Hormone_5

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	structure summary

Neurohypophysial hormones is a family of structurally and functionally related peptide hormones that includes oxytocin and vasopressin.

Hypophysis refers to the pituitary gland.

Oxytocin mediates contraction of the smooth muscle of the uterus and mammary gland, while vasopressin has antidiuretic action on the kidney, and mediates vasoconstriction of the peripheral vessels.^[1] In common with most active peptides, both hormones are synthesised as larger protein precursors that are enzymatically converted to their mature forms.

Members of this family are found in birds, fish, reptiles and amphibians (mesotocin, isotocin, valitocin, glumitocin, aspargtocin, vasotocin, seritocin, asvatocin, phasvatocin), in worms (annetocin), octopi (cephalotocin), Locusta migratoria (Migratory locust) (locupressin or neuropeptide F1/F2) and in molluscs (conopressins G and S).^[2]

[edit] References

^ Acher R, Chauvet J (1988). "Structure, processing and evolution of the neurohypophysial hormone-neurophysin precursors". Biochimie 70 (9): 1197–1207. doi:10.1016/0300-9084(88)90185-X. PMID 3147712.
^ Michel G, Acher R, Chauvet J, Ouedraogo Y, Chou J, Chait BT (1995). "A new neurohypophysial peptide, seritocin ([Ser5,Ile8]-oxytocin), identified in a dryness-resistant African toad, Bufo regularis". Int. J. Pept. Protein Res. 45 (5): 482–487. PMID 7591488.

This article incorporates text from the public domain Pfam and InterPro IPR000981

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Neurohypophysial hormones, C-terminal Domain

N-terminal Domain is in hormone5

External database links

PANDIT:	PF00184
PROSITE:	PDOC00237
Pseudofam:	PF00184
SCOP:	1xy2
SYSTERS:	Hormone_5

This tab holds annotation information from the InterPro database.

InterPro entry IPR000981

Oxytocin and vasopressin are nine-residue, structurally and functionally related neurohypophysial peptide hormones. Oxytocin mediates contraction of the smooth muscle of the uterus and mammary gland, while vasopressin has antidiuretic action on the kidney, and mediates vasoconstriction of the peripheral vessels [PUBMED:3147712]. In common with most active peptides, both hormones are synthesised as larger protein precursors that are enzymatically converted to their mature forms. Members of this family are found in birds, fish, reptiles and amphibians (mesotocin, isotocin, valitocin, glumitocin, aspargtocin, vasotocin, seritocin, asvatocin, phasvatocin), in worms (annetocin), octopi (cephalotocin), Locusta migratoria (Migratory locust) (locupressin or neuropeptide F1/F2) and in molluscs (conopressins G and S) [PUBMED:7591488].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Cellular component	extracellular region (GO:0005576)
Molecular function	neurohypophyseal hormone activity (GO:0005185)

Domain organisation

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Alignments

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Alignment:	Seed (36) Full (145) NCBI (203) Metagenomics
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Alignment:	Seed (36) Full (145)
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The main seed and full alignments are generated using sequences from the UniProt sequence database. However, we also generate alignments using sequences from the NCBI sequence database and the "metaseq" metagenomics dataset.

You can view alignments from these two additional datasets using the form above, or you can download alignments of NCBI or metagenomics sequences, as gzip-compressed files.

Pfam alignments:	Seed (36) Full (145) NCBI (203) Metagenomics
Full length sequences	Full-sequences (145)

External links

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Curation and family details

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Curation

Seed source:

Prosite

Previous IDs:

hormone5;

Type:

Family

Author:

Finn RD

Number in seed:

36

Number in full:

145

Average length of the domain:

76.60 aa

Average identity of full alignment:

62 %

Average coverage of the sequence by the domain:

55.76 %

HMM information

HMM build commands:

build method: hmmbuild -o /dev/null HMM SEED

search method: hmmsearch -Z 15929002 -E 1000 --cpu 4 HMM pfamseq

Model details:

Parameter	Sequence	Domain
Gathering cut-off	25.0	25.0
Trusted cut-off	25.0	31.4
Noise cut-off	18.8	24.2

Model length:

79

Family (HMM) version:

12

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Species distribution

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Archea	Eukaryota
Bacteria	Other sequences
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Interactions

There is 1 interaction for this family. More...

Hormone_5

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Hormone_5 domain has been found. There are 3 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.

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Family: Hormone_5 (PF00184)

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Summary: Neurohypophysial hormones, C-terminal Domain

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Editing Wikipedia articles

Before you edit for the first time

How your contribution will be recorded

Contact us

Neurohypophysial hormone

[edit] References

Neurohypophysial hormones, C-terminal Domain

External database links

InterPro entry IPR000981

Gene Ontology

Domain organisation

Alignments

Viewing

Downloading

View options

Formatting options

Download options

External links

HMM logo

Trees

Curation and family details

Curation

HMM information

Species distribution

Sunburst controls

Weight segments by...

Change the size of the sunburst

Colour assignments

How the sunburst is generated

Colouring and labels

Anomalies in the taxonomy tree

Missing taxonomic levels

Unmapped species names

Sub-species

Too many species/sequences

Tree controls

Annotation

Download tree

Selected sequences

Species trees

Interactive tree

Interactions

Structures