Summary: Serine hydroxymethyltransferase
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Serine hydroxymethyltransferase Provide feedback
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Internal database links
|Similarity to PfamA using HHSearch:||Aminotran_1_2 Aminotran_5 Beta_elim_lyase Cys_Met_Meta_PP|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR001085
Serine hydroxymethyltransferase (SHMT) is a pyridoxal phosphate (PLP) dependent enzyme and belongs to the aspartate aminotransferase superfamily (fold type I) [PUBMED:10828359]. The pyridoxal-P group is attached to a lysine residue around which the sequence is highly conserved in all forms of the enzyme [PUBMED:8305478]. The enzyme carries out interconversion of serine and glycine using PLP as the cofactor. SHMT catalyses the transfer of a hydroxymethyl group from N5, N10- methylene tetrahydrofolate to glycine, resulting in the formation of serine and tetrahydrofolate. Both eukaryotic and prokaryotic SHMT enzymes form tight obligate homodimers and the mammalian enzyme forms a homotetramer [PUBMED:10828359, PUBMED:11877399].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||glycine hydroxymethyltransferase activity (GO:0004372)|
|Biological process||glycine metabolic process (GO:0006544)|
|L-serine metabolic process (GO:0006563)|
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Curation and family details
|Number in seed:||12|
|Number in full:||6460|
|Average length of the domain:||351.50 aa|
|Average identity of full alignment:||52 %|
|Average coverage of the sequence by the domain:||88.05 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||14|
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