Summary: Glycosyl transferase family 2
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Glycosyl transferase family 2 Provide feedback
Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.
Internal database links
|Similarity to PfamA using HHSearch:||GNT-I Osmo_MPGsynth Glyco_tranf_2_2 Rhamno_transf Glyco_transf_21 Glyco_trans_2_3 Glyco_tranf_2_3 Glyco_tranf_2_4 Glyco_tranf_2_5|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR001173
The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates (EC) and related proteins into distinct sequence based families has been described [PUBMED:9334165]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.This domain is found in a diverse family of glycosyl transferases that transfer the sugar from UDP-glucose, UDP-N-acetyl-galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||MRC-LMB Genome group|
|Number in seed:||253|
|Number in full:||43678|
|Average length of the domain:||163.70 aa|
|Average identity of full alignment:||16 %|
|Average coverage of the sequence by the domain:||45.40 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||21|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Glycos_transf_2 domain has been found. There are 41 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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