Summary: Class II Aldolase and Adducin N-terminal domain
Class II Aldolase and Adducin N-terminal domain Provide feedback
This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR001303
This entry represents the alpha/beta/alpha domain found in class II aldolases and in adducin (usually at the N terminus of adducin). Proteins containing this domain include: rhamnulose-1-phosphate aldolase (EC), L-fuculose phosphate aldolase (EC) [PUBMED:8515438, PUBMED:8676381] that is involved in the third step in fucose metabolism, L-ribulose- 5-phosphate 4-epimerase (EC) involved in the third step of L-arabinose catabolism, a probable sugar isomerase SgbE and the metazoan adducins, which have not been ascribed any enzymatic function but which play a role in cell membrane cytoskeleton organisation [PUBMED:1840603].
|Molecular function||metal ion binding (GO:0046872)|
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
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We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
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- alignment generated by searching the NCBI sequence database using the family HMM
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Curation and family details
|Seed source:||MRC-LMB Genome Group|
|Number in seed:||502|
|Number in full:||9699|
|Average length of the domain:||184.40 aa|
|Average identity of full alignment:||24 %|
|Average coverage of the sequence by the domain:||69.68 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||16|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Aldolase_II domain has been found. There are 97 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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