Summary: Influenza Matrix protein (M1)
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Influenza Matrix protein (M1) Provide feedback
This protein forms a continuous shell on the inner side of the lipid bilayer, but its function is unclear.
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR001561
Matrix protein (M1) of Influenza virus is a bifunctional membrane/RNA-binding protein that mediates the encapsidation of RNA-nucleoprotein cores into the membrane envelope. It is therefore required that M1 binds both membrane and RNA simultaneously [PUBMED:9164466]. M1 is comprised of two domains connected by a linker sequence. The N-terminal domain has a multi-helical structure that can be divided into two subdomains [PUBMED:11162800]. The C-terminal domain also contains alpha-helical structure.
|Molecular function||RNA binding (GO:0003723)|
|structural molecule activity (GO:0005198)|
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Curation and family details
|Seed source:||Bateman A|
|Number in seed:||2|
|Number in full:||22622|
|Average length of the domain:||152.20 aa|
|Average identity of full alignment:||94 %|
|Average coverage of the sequence by the domain:||61.75 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||14|
|Download:||download the raw HMM for this family|
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There is 1 interaction for this family. More...
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Flu_M1 domain has been found. There are 27 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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