Summary: Viral matrix protein
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Viral matrix protein Edit Wikipedia article
|This article does not cite any references or sources. (December 2009)|
||It has been suggested that this article or section be merged with Retroviral matrix protein. (Discuss) Proposed since June 2011.|
|Viral matrix protein|
Viral matrix proteins are structural proteins linking the viral envelope with the virus core. They play a crucial role in virus assembly, and interact with the RNP complex as well as with the viral membrane. They are found in Morbillivirus, Paramyxovirus, Orthomyxovirus and Pneumovirus.(See for instance Battisti et al. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):13996-400.
An example is the M1 protein of the influenza virus, showing affinity to the glycoproteins inserted in the host cell membrane on one side and affinity for the RNP complex molecules on the other side, which allows formation at the membrane of a complex made of the viral ribonucleoprotein at the inner side indirectly connected to the viral glycoproteins protruding from the membrane. This assembly complex will now bud out of the cell as new mature viruses.
Viral matrix proteins, like many other viral proteins may exert different functions during the course of the infection.
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Found in Morbillivirus and paramyxovirus, pneumovirus.
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR000982
The matrix protein plays a crucial role in virus assembly, and interacts with the RNP complex as well as with the viral membrane. It is found in Morbillivirus, Paramyxovirus, Pneumovirus.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||structural molecule activity (GO:0005198)|
|Biological process||virion assembly (GO:0019068)|
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Curation and family details
|Seed source:||Pfam-B_128 (release 2.1)|
|Number in seed:||13|
|Number in full:||784|
|Average length of the domain:||266.80 aa|
|Average identity of full alignment:||48 %|
|Average coverage of the sequence by the domain:||96.27 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||16|
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