Summary: Gram positive anchor
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Gram positive anchor Provide feedback
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External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR019948
Viruses, parasites and bacteria are covered in protein and sugar molecules that help them gain entry into a host by counteracting the host's defences. One such molecule is the M protein produced by certain streptococcal bacteria. M proteins embody a motif that is now known to be shared by many Gram-positive bacterial surface proteins. The motif includes a conserved hexapeptide, which precedes a hydrophobic C-terminal membrane anchor, which itself precedes a cluster of basic residues [PUBMED:2188957, PUBMED:2287281]. This structure is represented in the following schematic representation:
+--------------------------------------------+-+--------+-+ | Variable length extracellular domain |H| Anchor |B| +--------------------------------------------+-+--------+-+ 'H': conserved hexapeptide. 'B': cluster of basic residues.
It has been proposed that this hexapeptide sequence is responsible for a post- translational modification necessary for the proper anchoring of the proteins which bear it, to the cell wall.
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_457 (release 2.1)|
|Number in seed:||84|
|Number in full:||9438|
|Average length of the domain:||38.70 aa|
|Average identity of full alignment:||27 %|
|Average coverage of the sequence by the domain:||4.73 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||16|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Gram_pos_anchor domain has been found. There are 11 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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