Summary: Sodium:sulfate symporter transmembrane region
Sodium:sulfate symporter transmembrane region Provide feedback
There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Internal database links
|Similarity to PfamA using HHSearch:||CitMHS CitMHS DcuC DctM|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR001898
Integral membrane proteins that mediate the intake of a wide variety of molecules with the concomitant uptake of sodium ions (sodium symporters) can be grouped, on the basis of sequence and functional similarities into a number of distinct families. One of these families currently consists of the following proteins:
- Mammalian sodium/sulphate cotransporter [PUBMED:7690140].
- Mammalian renal sodium/dicarboxylate cotransporter [PUBMED:8967342], which transports succinate and citrate.
- Mammalian intestinal sodium/dicarboxylate cotransporter.
- Chlamydomonas reinhardtii putative sulphur deprivation response regulator SAC1 [PUBMED:8641280].
- Caenorhabditis elegans hypothetical proteins B0285.6, F31F6.6, K08E5.2 and R107.1.
- Escherichia coli hypothetical protein yfbS.
- Haemophilus influenzae hypothetical protein HI0608.
- Synechocystis sp. (strain PCC 6803) hypothetical protein sll0640.
- Methanocaldococcus jannaschii (Methanococcus jannaschii) hypothetical protein MJ0672.
These transporters are proteins of from 430 to 620 amino acids which are highly hydrophobic and which probably contain about 12 transmembrane regions.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||membrane (GO:0016020)|
|Molecular function||transporter activity (GO:0005215)|
|Biological process||transmembrane transport (GO:0055085)|
|sodium ion transport (GO:0006814)|
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
- the Pfam graphic itself.
Loading domain graphics...
This superfamily of secondary carriers specific for cationic and anionic compounds, has been termed the ion transporter (IT) superfamily .
The clan contains the following 17 members:ABG_transport ArsB CitMHS DctM DcuA_DcuB DcuC DUF1504 DUF1646 DUF401 GntP_permease Lactate_perm MatC_N Na_H_antiport_2 Na_H_antiporter Na_sulph_symp NhaB SCFA_trans
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
- Pfam viewer
- an HTML-based viewer that uses DAS to retrieve alignment fragments on request
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
Format an alignment
If you find these logos useful in your own work, please consider citing the following article:
Note: You can also download the data file for the tree.
Curation and family details
|Seed source:||Pfam-B_1100 (release 3.0)|
|Author:||Finn RD, Bateman A|
|Number in seed:||11|
|Number in full:||6208|
|Average length of the domain:||426.10 aa|
|Average identity of full alignment:||24 %|
|Average coverage of the sequence by the domain:||91.05 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||14|
|Download:||download the raw HMM for this family|
Weight segments by...
Change the size of the sunburst
selected sequences to HMM
a FASTA-format file
- 0 sequences
- 0 species
How the sunburst is generated
Colouring and labels
Anomalies in the taxonomy tree
Missing taxonomic levels
Unmapped species names
Too many species/sequences
The tree shows the occurrence of this domain across different species. More...
You can use the tree controls to manipulate how the interactive tree is displayed:
- show/hide the summary boxes
- highlight species that are represented in the seed alignment
- expand/collapse the tree or expand it to a given depth
- select a sub-tree or a set of species within the tree and view them graphically or as an alignment
- save a plain text representation of the tree