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7  structures 144  species 1  interaction 234  sequences 6  architectures

Family: ER (PF01133)

Summary: Enhancer of rudimentary

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This is the Wikipedia entry entitled "ERH (gene)". More...

ERH (gene) Edit Wikipedia article

Enhancer of rudimentary homolog (Drosophila)

PDB rendering based on 1w9g.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ERH; DROER
External IDs OMIM601191 MGI108089 HomoloGene3274 GeneCards: ERH Gene
RNA expression pattern
PBB GE ERH 200043 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2079 13877
Ensembl ENSG00000100632 ENSMUSG00000021131
UniProt P84090 P84089
RefSeq (mRNA) NM_004450 NM_007951
RefSeq (protein) NP_004441 NP_031977
Location (UCSC) Chr 14:
69.85 – 69.87 Mb
Chr 12:
80.63 – 80.64 Mb
PubMed search [1] [2]
Enhancer of rudimentary
PDB 1wz7 EBI.jpg
crystal structure of enhancer of rudimentary homologue (erh)
Identifiers
Symbol ER
Pfam PF01133
InterPro IPR000781
PROSITE PDOC00732
SCOP 1j24
SUPERFAMILY 1j24
TCDB 3.A.16

In molecular biology, Enhancer of rudimentary homolog is a protein that in humans is encoded by the ERH gene.[1][2][3]

The Drosophila protein enhancer of rudimentary protein is a small protein of 104 amino acids. It has been found to be an enhancer of the rudimentary gene, involved in pyrimidine biosynthesis.[4]

From an evolutionary point of view, enhancer of rudimentary is highly conserved and has been found to exist in probably all multicellular eukaryotic organisms.[2] It has been proposed that this protein plays a role in the cell cycle.


References[edit]

  1. ^ Isomura M, Okui K, Fujiwara T, Shin S, Nakamura Y (Sep 1996). "Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene". Genomics 32 (1): 125–7. doi:10.1006/geno.1996.0086. PMID 8786099. 
  2. ^ a b Gelsthorpe M, Pulumati M, McCallum C, Dang-Vu K, Tsubota SI (Apr 1997). "The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals". Gene 186 (2): 189–95. doi:10.1016/S0378-1119(96)00701-9. PMID 9074495. 
  3. ^ "Entrez Gene: ERH enhancer of rudimentary homolog (Drosophila)". 
  4. ^ Wojcik, E.; Murphy, A. M.; Fares, H.; Dang-Vu, K.; Tsubota, S. I. (1994). "Enhancer of rudimentaryp1, e(r)p1, a highly conserved enhancer of the rudimentary gene". Genetics 138 (4): 1163–1170. PMC 1206255. PMID 7896098.  edit

Further reading[edit]


This article incorporates text from the public domain Pfam and InterPro IPR000781

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Enhancer of rudimentary Provide feedback

Enhancer of rudimentary is a protein of unknown function that is highly conserved in plants and animals. This protein is found to be an enhancer of the rudimentary gene P05990.

Literature references

  1. Wojcik E, Murphy AM, Fares H, Dang-Vu K, Tsubota SI; , Genetics 1994;138:1163-1170.: Enhancer of rudimentaryp1, e(r)p1, a highly conserved enhancer of the rudimentary gene. PUBMED:7896098 EPMC:7896098

  2. Gelsthorpe M, Pulumati M, McCallum C, Dang-Vu K, Tsubota SI; , Gene 1997;186:189-195.: The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals. PUBMED:9074495 EPMC:9074495


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000781

The Drosophila protein 'enhancer of rudimentary' (gene (e(r)) is a small protein of 104 residues whose function is not yet clear. From an evolutionary point of view, it is highly conserved [PUBMED:9074495] and has been found to exist in probably all multicellular eukaryotic organisms. It has been proposed that this protein plays a role in the cell cycle.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(13)
Full
(234)
Representative proteomes NCBI
(192)
Meta
(0)
RP15
(44)
RP35
(65)
RP55
(117)
RP75
(154)
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  Seed
(13)
Full
(234)
Representative proteomes NCBI
(192)
Meta
(0)
RP15
(44)
RP35
(65)
RP55
(117)
RP75
(154)
Alignment:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(13)
Full
(234)
Representative proteomes NCBI
(192)
Meta
(0)
RP15
(44)
RP35
(65)
RP55
(117)
RP75
(154)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download    
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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

Pfam alignments:

HMM logo

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This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: none
Type: Family
Author: Finn RD, Bateman A
Number in seed: 13
Number in full: 234
Average length of the domain: 97.70 aa
Average identity of full alignment: 53 %
Average coverage of the sequence by the domain: 65.02 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.0 25.0
Trusted cut-off 25.7 34.1
Noise cut-off 20.9 24.1
Model length: 103
Family (HMM) version: 12
Download: download the raw HMM for this family

Species distribution

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Interactions

There is 1 interaction for this family. More...

ER

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the ER domain has been found. There are 7 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.

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