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21  structures 66  species 0  interactions 168  sequences 2  architectures

Family: Parathyroid (PF01279)

Summary: Parathyroid hormone family

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This is the Wikipedia entry entitled "Parathyroid hormone family". More...

Parathyroid hormone family Edit Wikipedia article

Parathyroid hormone family
Identifiers
Symbol Parathyroid
Pfam PF01279
InterPro IPR001415
PROSITE PDOC00296
SCOP 1zwg
SUPERFAMILY 1zwg

The parathyroid hormone family is a family of structurally and functionally related proteins. Parathyroid hormone (PTH) is a polypeptidic hormone primarily involved in calcium metabolism. The parathyroid hormone-related protein (PTH-rP) is a related protein with predominantly paracrine function and possibly an endocrine role in lactation, as PTHrP has been found to be secreted by mammary glands into the circulation and increase bone turnover.[1][2] PTH and PTH-rP bind to the same G-protein coupled receptor.[3] The related protein PTH-L has been found in teleost fish, which also have two forms of PTH and PTHrP.[4] Three subfamilies can be identified: PTH, PTHrP and PTH-L.[5]

Human proteins containing this domain[edit]

PTH; PTHLH;

References[edit]

  1. ^ VanHouten JN, Dann P, Stewart AF, Watson CJ, Pollak M, Karaplis AC, Wysolmerski JJ (November 2003). "Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation". J. Clin. Invest. 112 (9): 1429–36. doi:10.1172/JCI19504. PMC 228471. PMID 14597768. 
  2. ^ McCauley LK, Martin TJ (June 2012). "Twenty-five years of PTHrP progress: from cancer hormone to multifunctional cytokine". J. Bone Miner. Res. 27 (6): 1231–9. doi:10.1002/jbmr.1617. PMID 22549910. 
  3. ^ Martin TJ, Allan EH, Caple IW, Care AD, Danks JA, Diefenbach-Jagger H, Ebeling PR, Gillespie MT, Hammonds G, Heath JA (1989). "Parathyroid hormone-related protein: isolation, molecular cloning, and mechanism of action". Recent Prog. Horm. Res. 45: 467–502; discussion 502–6. PMID 2682846. 
  4. ^ Pinheiro PL, Cardoso JC, Gomes AS, Fuentes J, Power DM, Canário AV (2010). "Gene structure, transcripts and calciotropic effects of the PTH family of peptides in Xenopus and chicken". BMC Evol. Biol. 10: 373. doi:10.1186/1471-2148-10-373. PMC 3009671. PMID 21122104. 
  5. ^ Guerreiro PM, Renfro JL, Power DM, Canario AV (February 2007). "The parathyroid hormone family of peptides: structure, tissue distribution, regulation, and potential functional roles in calcium and phosphate balance in fish". Am. J. Physiol. Regul. Integr. Comp. Physiol. 292 (2): R679–96. doi:10.1152/ajpregu.00480.2006. PMID 17023665. 

This article incorporates text from the public domain Pfam and InterPro IPR001415

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No Pfam abstract.

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001415

Parathyroid hormone (PTH) is a polypeptidic hormone that elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Parathyroid hormone-related protein (PTH-rP) is structurally related to PTH [PUBMED:2682846] and seems to play a physiological role in lactation, possibly as a hormone for the mobilisation and/or transfer of calcium to the milk. It also regulates chondrocytic differentiation and endochondral bone formation [PUBMED:11760831].

PTH and PTH-rP bind to the same G-protein coupled receptor.

This entry represents parathyroid hormone and parathyroid hormone-related protein.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the NCBI sequence database, and our metagenomics sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(11)
Full
(168)
Representative proteomes NCBI
(160)
Meta
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RP15
(3)
RP35
(8)
RP55
(27)
RP75
(66)
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Format an alignment

  Seed
(11)
Full
(168)
Representative proteomes NCBI
(160)
Meta
(0)
RP15
(3)
RP35
(8)
RP55
(27)
RP75
(66)
Alignment:
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Sequence:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(11)
Full
(168)
Representative proteomes NCBI
(160)
Meta
(0)
RP15
(3)
RP35
(8)
RP55
(27)
RP75
(66)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

Pfam alignments:

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: none
Type: Family
Author: Finn RD, Bateman A
Number in seed: 11
Number in full: 168
Average length of the domain: 89.80 aa
Average identity of full alignment: 41 %
Average coverage of the sequence by the domain: 64.87 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild --amino -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 19.7 19.7
Trusted cut-off 20.9 20.0
Noise cut-off 19.4 19.3
Model length: 100
Family (HMM) version: 12
Download: download the raw HMM for this family

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Parathyroid domain has been found. There are 21 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.

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