Summary: SEA domain
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SEA domain Provide feedback
Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain .
Kitamoto Y, Yuan X, Wu Q, McCourt DW, Sadler JE; , Proc Natl Acad Sci U S A 1994;91:7588-7592.: Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains. PUBMED:8052624 EPMC:8052624
Maeda T, Inoue M, Koshiba S, Yabuki T, Aoki M, Nunokawa E, Seki E, Matsuda T, Motoda Y, Kobayashi A, Hiroyasu F, Shirouzu M, Terada T, Hayami N, Ishizuka Y, Shinya N, Tatsuguchi A, Yoshida M, Hirota H, Matsuo Y, Tani K, Arakawa T, Carninci P, Kawai J, Hay, J Biol Chem 2004;279:13174-13182.: Solution structure of the SEA domain from the murine homologue of ovarian cancer antigen CA125 (MUC16). PUBMED:14764598 EPMC:14764598
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR000082SEA is an extracellular domain associated with O-glycosylation [PUBMED:7670383]. Proteins found to contain SEA-modules include, agrin, enterokinase, 63 kDa Strongylocentrotus purpuratus (Purple sea urchin) sperm protein, perlecan (heparan sulphate proteoglycan core, mucin 1 and the cell surface antigen, 114/A10, and two functionally uncharacterised, probably extracellular, Caenorhabditis elegans proteins. Despite the functional diversity of these adhesive proteins, a common denominator seems to be their existence in heavily glycosylated environments. In addition, the better characterised proteins all contain O-glycosidic-linked carbohydrates such as heparan sulphate that contribute considerably to their molecular masses. The common module might regulate or assist binding to neighbouring carbohydrate moieties.
Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains [PUBMED:8052624].
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Curation and family details
|Number in seed:||94|
|Number in full:||1758|
|Average length of the domain:||104.30 aa|
|Average identity of full alignment:||16 %|
|Average coverage of the sequence by the domain:||14.60 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||15|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the SEA domain has been found. There are 4 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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