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Galactosyltransferase Edit Wikipedia article
Galactosyltransferase is a type of glycosyltransferase which catalyzes the transfer of galactose. An example is B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase.
The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates (EC 2.4.1.-) and related proteins into distinct sequence based families has been described. This classification is available on the CAZy (Carbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.
Glycosyltransferase family 31 (CAZY GH_31) comprises enzymes with a number of known activities; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase (EC 22.214.171.124); beta-1,3-galactosyltransferase (EC 2.4.1); fucose-specific beta-1,3-N-acetylglucosaminyltransferase (EC 2.4.1); globotriosylceramide beta-1,3-GalNAc transferase (EC 126.96.36.199).
 Human galactosyltransferases
- ^ Henrissat B, Davies GJ, Campbell JA, Bulone V (1997). "A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities". Biochem. J. 326: 929–939. PMC 1218753. PMID 9334165. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1218753.
- ^ Henrissat B, Coutinho PM (1999). Carbohydrate-Active Enzymes server. pp. -.
- ^ Kolbinger F, Streiff MB, Katopodis AG (1998). "Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase catalyzing the formation of type 1 chains". J. Biol. Chem. 273 (1): 433–440. doi:10.1074/jbc.273.1.433. PMID 9417100.
- ^ Hennet T, Dinter A, Kuhnert P, Mattu TS, Rudd PM, Berger EG (1998). "Genomic cloning and expression of three murine UDP-galactose: beta-N-acetylglucosamine beta1,3-galactosyltransferase genes". J. Biol. Chem. 273 (1): 58–65. doi:10.1074/jbc.273.1.58. PMID 9417047.
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Galactosyltransferase Provide feedback
This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferas e O43825  and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase O54904 . Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2 .
Kolbinger F, Streiff MB, Katopodis AG; , J Biol Chem 1998;273:433-440.: Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta- galactosyltransferase catalyzing the formation of type 1 chains. PUBMED:9417100 EPMC:9417100
Hennet T, Dinter A, Kuhnert P, Mattu TS, Rudd PM, Berger EG; , J Biol Chem 1998;273:58-65.: Genomic cloning and expression of three murine UDP-galactose: beta-N- acetylglucosamine beta1,3-galactosyltransferase genes. PUBMED:9417047 EPMC:9417047
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR002659
The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates (EC) and related proteins into distinct sequence based families has been described [PUBMED:9334165]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.
Glycosyltransferase family 31 (CAZY) comprises enzymes with a number of known activities; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase (EC); beta-1,3-galactosyltransferase (EC); fucose-specific beta-1,3-N-acetylglucosaminyltransferase (EC); globotriosylceramide beta-1,3-GalNAc transferase (EC) [PUBMED:9417100, PUBMED:9417047].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||membrane (GO:0016020)|
|Molecular function||galactosyltransferase activity (GO:0008378)|
|Biological process||protein glycosylation (GO:0006486)|
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|Seed source:||Pfam-B_885 (release 4.2)|
|Author:||Bashton M, Bateman A|
|Number in seed:||14|
|Number in full:||2182|
|Average length of the domain:||177.90 aa|
|Average identity of full alignment:||24 %|
|Average coverage of the sequence by the domain:||47.89 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||16|
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