Summary: RibD C-terminal domain
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RibD C-terminal domain Provide feedback
The function of this domain is not known, but it is thought to be involved in riboflavin biosynthesis. This domain is found in the C terminus of RibD/RibG P25539 in combination with PF00383 as well as in isolation in some archaebacterial proteins P95872. This family appears to be related to PF00186.
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR002734This domain is found in the C terminus of the bifunctional deaminase-reductase of Escherichia coli, Bacillus subtilis and other bacteria in combination with INTERPRO that catalyses the second and third steps in the biosynthesis of riboflavin, i.e., the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (deaminase) and the subsequent reduction of the ribosyl side chain (reductase) [PUBMED:9068650]. The domain is also present in some HTP reductases from archaea and fungi.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||5-amino-6-(5-phosphoribosylamino)uracil reductase activity (GO:0008703)|
|Biological process||riboflavin biosynthetic process (GO:0009231)|
|oxidation-reduction process (GO:0055114)|
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Curation and family details
|Seed source:||Enright A & Pfam-B_6425 (Release 8.0)|
|Author:||Enright A, Ouzounis C, Bateman A|
|Number in seed:||27|
|Number in full:||7001|
|Average length of the domain:||188.90 aa|
|Average identity of full alignment:||22 %|
|Average coverage of the sequence by the domain:||66.43 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||12|
|Download:||download the raw HMM for this family|
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There are 2 interactions for this family. More...
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the RibD_C domain has been found. There are 36 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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