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mTERF Provide feedback
This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer . The leucine zippers are not implicated in a dimerisation role as in other leucine zippers .
Fernandez-Silva P, Martinez-Azorin F, Micol V, Attardi G; , EMBO J 1997;16:1066-1079.: The human mitochondrial transcription termination factor (mTERF) is a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions. PUBMED:9118945 EPMC:9118945
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This tab holds annotation information from the InterPro database.
InterPro entry IPR003690
This family currently contains one sequence of known function human mitochondrial transcription termination factor (mTERF), a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions [PUBMED:9118945]. The precursors contain a mitochondrial targeting sequence, and the mature mTERF exhibits three leucine zippers, of which one is bipartite, and two widely spaced basic domains. Both basic domains and the three leucine zipper motifs are necessary for DNA binding. The leucine zippers are not implicated in a dimerisation role as in other leucine zippers [PUBMED:9118945].
The rest of the family consists of hypothetical proteins none of which have any functional information.
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Curation and family details
|Seed source:||Pfam-B_1422 (release 5.4)|
|Author:||Bashton M, Bateman A|
|Number in seed:||15|
|Number in full:||1485|
|Average length of the domain:||187.20 aa|
|Average identity of full alignment:||13 %|
|Average coverage of the sequence by the domain:||64.71 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||9|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the mTERF domain has been found. There are 8 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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