Summary: Exonuclease VII small subunit
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Exonuclease VII Edit Wikipedia article
|Exonuclease VII, large subunit|
|Exonuclease VII small subunit|
|crystal structure of exodeoxyribonuclease vii small subunit (np_881400.1) from bordetella pertussis at 2.40 a resolution|
In molecular biology, exonuclease VII (EC 184.108.40.206, Escherichia coli exonuclease VII, E. coli exonuclease VII, endodeoxyribonuclease VII, Exodeoxyribonuclease VII) is a bacterial exonuclease enzyme. It is composed of two nonidentical subunits; one large subunit and 4 small ones. Exonuclease VII catalyses exonucleolytic cleavage in either 5'-3' or 3'-5' direction to yield 5'-phosphomononucleotides. The large subunit also contains an N-terminal OB-fold domain that binds to nucleic acids.
- Chase, J.W. and Richardson, C.C. (1974). "Ribonuclease VII of Escherichia coli". J. Biol. Chem. 249 (14): 4545–4552. PMID 4602029.
- Chase, J.W. and Richardson, C.C. (1974). "Exonuclease VII of Escherichia coli". J. Biol. Chem. 249 (14): 4553–4561. PMID 4602030.
- Vales LD, Rabin BA, Chase JW (August 1982). "Subunit structure of Escherichia coli exonuclease VII". J. Biol. Chem. 257 (15): 8799–805. PMID 6284744.
Exonuclease VII small subunit Provide feedback
This family consist of exonuclease VII, small subunit EC:220.127.116.11 This enzyme catalyses exonucleolytic cleavage in either 5'->3' or 3'->5' direction to yield 5'-phosphomononucleotides. This exonuclease VII enzyme is composed of one large subunit and 4 small ones .
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR003761
Exonuclease VII is composed of two non-identical subunits; one large subunit and 4 small ones [PUBMED:6284744]. This enzyme catalyses exonucleolytic cleavage in either 5'-3' or 3'-5' direction to yield nucleoside 5'-phosphates.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||exodeoxyribonuclease VII complex (GO:0009318)|
|Molecular function||exodeoxyribonuclease VII activity (GO:0008855)|
|Biological process||DNA catabolic process (GO:0006308)|
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|Author:||Bashton M, Bateman A|
|Number in seed:||148|
|Number in full:||4033|
|Average length of the domain:||52.90 aa|
|Average identity of full alignment:||37 %|
|Average coverage of the sequence by the domain:||66.86 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||11|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Exonuc_VII_S domain has been found. There are 6 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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