Summary: YceG-like family
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YceG-like family Provide feedback
This family of proteins is found in bacteria. Proteins in this family are typically between 332 and 389 amino acids in length. This family was previously incorrectly annotated and names as aminodeoxychorismate lyase. The structure of P28306 was solved by X-ray crystallography.
Jhee KH, Yoshimura T, Miles EW, Takeda S, Miyahara I, Hirotsu K, Soda K, Kawata Y, Esaki N; , J Biochem (Tokyo) 2000;128:679-686.: Stereochemistry of the transamination reaction catalyzed by aminodeoxychorismate lyase from Escherichia coli: close relationship between fold type and stereochemistry. PUBMED:11011151 EPMC:11011151
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This tab holds annotation information from the InterPro database.
InterPro entry IPR003770
This uncharacterised protein family, found in three of four microbial genomes, virtually always once per genome, includes YceG from Escherichia coli. Proteins in this family are typically between 332 and 389 amino acids in length. This protein is encoded next to PabC, 4-amino-4-deoxychorismate lyase, in Escherichia coli and numerous other proteobacteria, but that proximity is not conserved in other lineages. Numerous members of this family have been misannotated as aminodeoxychorismate lyase, apparently because of promiximty to PabC. The structure of Swiss:P28306 was solved by X-ray crystallography.
This group represents an uncharacterised protein family UPF0755.
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Previous IDs:||DUF175; ADC_lyase;|
|Author:||Mian N, Bateman A, Moxon SJ|
|Number in seed:||195|
|Number in full:||4001|
|Average length of the domain:||281.50 aa|
|Average identity of full alignment:||30 %|
|Average coverage of the sequence by the domain:||77.07 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||11|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the YceG domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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